FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073789025> ?p ?o ?g. }

• W2073789025 endingPage "93" @default.
• W2073789025 startingPage "87" @default.
• W2073789025 abstract "p53 is required for DNA damage-induced apoptosis, which is central to its function as a tumour suppressor. Here, we show that the apoptotic defect of p53-deficient cells is nearly completely rescued by inactivation of any of the three subunits of the DNA repair holoenzyme DNA-dependent protein kinase (DNA-PK). Intestinal crypt cells from p53 nullizygous mice were resistant to radiation-induced apoptosis, whereas apoptosis in DNA-PK(cs)/p53, Ku80/p53 and Ku70/p53 double-null mice was quantitatively equivalent to that seen in wild-type mice. This p53-independent apoptotic response was specific to the loss of DNA-PK, as it was not seen in ligase IV (Lig4)/p53 or ataxia telangiectasia mutated (Atm)/p53 double-null mice. Furthermore, it was associated with an increase in phospho-checkpoint kinase 2 (CHK2), and cleaved caspases 3 and 9, the latter indicating engagement of the intrinsic apoptotic pathway. This shows that there are two separate, but equally effective, apoptotic responses to DNA damage: one is p53 dependent and the other, engaged in the absence of DNA-PK, does not require p53." @default.
• W2073789025 created "2016-06-24" @default.
• W2073789025 creator A5019966875 @default.
• W2073789025 creator A5020966290 @default.
• W2073789025 creator A5050031787 @default.
• W2073789025 creator A5058514854 @default.
• W2073789025 creator A5059494016 @default.
• W2073789025 date "2008-12-05" @default.
• W2073789025 modified "2023-10-11" @default.
• W2073789025 title "DNA‐PK suppresses a p53‐independent apoptotic response to DNA damage" @default.
• W2073789025 cites W1595815978 @default.
• W2073789025 cites W1604468403 @default.
• W2073789025 cites W1966254852 @default.
• W2073789025 cites W1991455654 @default.
• W2073789025 cites W1992688638 @default.
• W2073789025 cites W1995842427 @default.
• W2073789025 cites W1998530321 @default.
• W2073789025 cites W2002231685 @default.
• W2073789025 cites W2010711320 @default.
• W2073789025 cites W2017351036 @default.
• W2073789025 cites W2029304297 @default.
• W2073789025 cites W2032361307 @default.
• W2073789025 cites W2037670899 @default.
• W2073789025 cites W2040024642 @default.
• W2073789025 cites W2040881358 @default.
• W2073789025 cites W2043776284 @default.
• W2073789025 cites W2046589688 @default.
• W2073789025 cites W2047660841 @default.
• W2073789025 cites W2053926251 @default.
• W2073789025 cites W2057830803 @default.
• W2073789025 cites W2063669247 @default.
• W2073789025 cites W2075784029 @default.
• W2073789025 cites W2077800581 @default.
• W2073789025 cites W2111772438 @default.
• W2073789025 cites W2130728712 @default.
• W2073789025 cites W2132029465 @default.
• W2073789025 cites W2132780101 @default.
• W2073789025 cites W2144051580 @default.
• W2073789025 cites W2148760839 @default.
• W2073789025 cites W2151744500 @default.
• W2073789025 cites W2156257249 @default.
• W2073789025 cites W2163647257 @default.
• W2073789025 cites W2312862539 @default.
• W2073789025 cites W4250719896 @default.
• W2073789025 doi "https://doi.org/10.1038/embor.2008.214" @default.
• W2073789025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2613202" @default.
• W2073789025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19057578" @default.
• W2073789025 hasPublicationYear "2008" @default.
• W2073789025 type Work @default.
• W2073789025 sameAs 2073789025 @default.
• W2073789025 citedByCount "36" @default.
• W2073789025 countsByYear W20737890252012 @default.
• W2073789025 countsByYear W20737890252013 @default.
• W2073789025 countsByYear W20737890252015 @default.
• W2073789025 countsByYear W20737890252016 @default.
• W2073789025 countsByYear W20737890252017 @default.
• W2073789025 countsByYear W20737890252018 @default.
• W2073789025 countsByYear W20737890252019 @default.
• W2073789025 countsByYear W20737890252020 @default.
• W2073789025 countsByYear W20737890252021 @default.
• W2073789025 countsByYear W20737890252022 @default.
• W2073789025 countsByYear W20737890252023 @default.
• W2073789025 crossrefType "journal-article" @default.
• W2073789025 hasAuthorship W2073789025A5019966875 @default.
• W2073789025 hasAuthorship W2073789025A5020966290 @default.
• W2073789025 hasAuthorship W2073789025A5050031787 @default.
• W2073789025 hasAuthorship W2073789025A5058514854 @default.
• W2073789025 hasAuthorship W2073789025A5059494016 @default.
• W2073789025 hasBestOaLocation W20737890252 @default.
• W2073789025 hasConcept C104317684 @default.
• W2073789025 hasConcept C105696609 @default.
• W2073789025 hasConcept C134935766 @default.
• W2073789025 hasConcept C143425029 @default.
• W2073789025 hasConcept C153911025 @default.
• W2073789025 hasConcept C175114707 @default.
• W2073789025 hasConcept C190283241 @default.
• W2073789025 hasConcept C193104389 @default.
• W2073789025 hasConcept C2780919815 @default.
• W2073789025 hasConcept C2910325170 @default.
• W2073789025 hasConcept C29537977 @default.
• W2073789025 hasConcept C50001416 @default.
• W2073789025 hasConcept C502942594 @default.
• W2073789025 hasConcept C552990157 @default.
• W2073789025 hasConcept C55493867 @default.
• W2073789025 hasConcept C68748289 @default.
• W2073789025 hasConcept C86339819 @default.
• W2073789025 hasConcept C86803240 @default.
• W2073789025 hasConcept C94966510 @default.
• W2073789025 hasConcept C95444343 @default.
• W2073789025 hasConceptScore W2073789025C104317684 @default.
• W2073789025 hasConceptScore W2073789025C105696609 @default.
• W2073789025 hasConceptScore W2073789025C134935766 @default.
• W2073789025 hasConceptScore W2073789025C143425029 @default.
• W2073789025 hasConceptScore W2073789025C153911025 @default.
• W2073789025 hasConceptScore W2073789025C175114707 @default.
• W2073789025 hasConceptScore W2073789025C190283241 @default.
• W2073789025 hasConceptScore W2073789025C193104389 @default.
• W2073789025 hasConceptScore W2073789025C2780919815 @default.

• next