FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073789314> ?p ?o ?g. }

• W2073789314 endingPage "11577" @default.
• W2073789314 startingPage "11563" @default.
• W2073789314 abstract "At least two rate-limiting mechanisms in vesicle trafficking operate at mouse Schaffer collateral synapses, but their molecular/physical identities are unknown. The first mechanism determines the baseline rate at which reserve vesicles are supplied to a readily releasable pool. The second causes the supply rate to depress threefold when synaptic transmission is driven hard for extended periods. Previous models invoked depletion of a reserve vesicle pool to explain the reductions in the supply rate, but the mass-action assumption at their core is not compatible with kinetic measurements of neurotransmission under maximal-use conditions. Here we develop a new theoretical model of rate-limiting steps in vesicle trafficking that is compatible with previous and new measurements. A physical interpretation is proposed where local reserve pools consisting of four vesicles are tethered to individual release sites and are replenished stochastically in an all-or-none fashion. We then show that the supply rate depresses more rapidly in synapsin knock-outs and that the phenotype can be fully explained by changing the value of the single parameter in the model that would specify the size of the local reserve pools. Vesicle-trafficking rates between pools were not affected. Finally, optical imaging experiments argue against alternative interpretations of the theoretical model where vesicle trafficking is inhibited without reserve pool depletion. This new conceptual framework will be useful for distinguishing which of the multiple molecular and cell biological mechanisms involved in vesicle trafficking are rate limiting at different levels of synaptic throughput and are thus candidates for physiological and pharmacological modulation." @default.
• W2073789314 created "2016-06-24" @default.
• W2073789314 creator A5001783135 @default.
• W2073789314 creator A5021678681 @default.
• W2073789314 creator A5035994339 @default.
• W2073789314 creator A5041197792 @default.
• W2073789314 creator A5054729091 @default.
• W2073789314 creator A5078140696 @default.
• W2073789314 creator A5085251834 @default.
• W2073789314 creator A5087051489 @default.
• W2073789314 date "2011-08-10" @default.
• W2073789314 modified "2023-10-06" @default.
• W2073789314 title "A New Kinetic Framework for Synaptic Vesicle Trafficking Tested in Synapsin Knock-Outs" @default.
• W2073789314 cites W1487318093 @default.
• W2073789314 cites W1498241934 @default.
• W2073789314 cites W1517253433 @default.
• W2073789314 cites W1532309947 @default.
• W2073789314 cites W1533487444 @default.
• W2073789314 cites W1540799962 @default.
• W2073789314 cites W1568903867 @default.
• W2073789314 cites W1603483721 @default.
• W2073789314 cites W1685129917 @default.
• W2073789314 cites W1845163922 @default.
• W2073789314 cites W1965793946 @default.
• W2073789314 cites W1975923899 @default.
• W2073789314 cites W1979073092 @default.
• W2073789314 cites W1979354005 @default.
• W2073789314 cites W1989396363 @default.
• W2073789314 cites W1995855359 @default.
• W2073789314 cites W1997139942 @default.
• W2073789314 cites W2000746833 @default.
• W2073789314 cites W2001520037 @default.
• W2073789314 cites W2002209230 @default.
• W2073789314 cites W2002352665 @default.
• W2073789314 cites W2006766519 @default.
• W2073789314 cites W2010679521 @default.
• W2073789314 cites W2013948413 @default.
• W2073789314 cites W2014173681 @default.
• W2073789314 cites W2016779127 @default.
• W2073789314 cites W2019766891 @default.
• W2073789314 cites W2020602329 @default.
• W2073789314 cites W2022046189 @default.
• W2073789314 cites W2022104262 @default.
• W2073789314 cites W2030145065 @default.
• W2073789314 cites W2031543773 @default.
• W2073789314 cites W2043953994 @default.
• W2073789314 cites W2046620350 @default.
• W2073789314 cites W2049645639 @default.
• W2073789314 cites W2055374196 @default.
• W2073789314 cites W2060084426 @default.
• W2073789314 cites W2061655858 @default.
• W2073789314 cites W2065967745 @default.
• W2073789314 cites W2071358119 @default.
• W2073789314 cites W2071387048 @default.
• W2073789314 cites W2072389508 @default.
• W2073789314 cites W2073391931 @default.
• W2073789314 cites W2074688705 @default.
• W2073789314 cites W2076636373 @default.
• W2073789314 cites W2077481965 @default.
• W2073789314 cites W2084864774 @default.
• W2073789314 cites W2085825273 @default.
• W2073789314 cites W2086740370 @default.
• W2073789314 cites W2087176067 @default.
• W2073789314 cites W2088976329 @default.
• W2073789314 cites W2107092259 @default.
• W2073789314 cites W2125588021 @default.
• W2073789314 cites W2129696839 @default.
• W2073789314 cites W2139384331 @default.
• W2073789314 cites W2147170241 @default.
• W2073789314 cites W2149593291 @default.
• W2073789314 cites W2153700958 @default.
• W2073789314 cites W2155535919 @default.
• W2073789314 cites W2163693596 @default.
• W2073789314 cites W4302617909 @default.
• W2073789314 doi "https://doi.org/10.1523/jneurosci.1447-11.2011" @default.
• W2073789314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6623131" @default.
• W2073789314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21832187" @default.
• W2073789314 hasPublicationYear "2011" @default.
• W2073789314 type Work @default.
• W2073789314 sameAs 2073789314 @default.
• W2073789314 citedByCount "29" @default.
• W2073789314 countsByYear W20737893142012 @default.
• W2073789314 countsByYear W20737893142013 @default.
• W2073789314 countsByYear W20737893142015 @default.
• W2073789314 countsByYear W20737893142016 @default.
• W2073789314 countsByYear W20737893142019 @default.
• W2073789314 countsByYear W20737893142020 @default.
• W2073789314 countsByYear W20737893142021 @default.
• W2073789314 countsByYear W20737893142022 @default.
• W2073789314 crossrefType "journal-article" @default.
• W2073789314 hasAuthorship W2073789314A5001783135 @default.
• W2073789314 hasAuthorship W2073789314A5021678681 @default.
• W2073789314 hasAuthorship W2073789314A5035994339 @default.
• W2073789314 hasAuthorship W2073789314A5041197792 @default.
• W2073789314 hasAuthorship W2073789314A5054729091 @default.
• W2073789314 hasAuthorship W2073789314A5078140696 @default.
• W2073789314 hasAuthorship W2073789314A5085251834 @default.
• W2073789314 hasAuthorship W2073789314A5087051489 @default.

• next