Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073789511> ?p ?o ?g. }
- W2073789511 endingPage "610" @default.
- W2073789511 startingPage "605" @default.
- W2073789511 abstract "Liver damage is more prevalent among obese alcoholics, and cytochrome P-4502E1(CYP2E1) induction is involved in its pathogenesis.The study was undertaken to assess microsomal function, in alcoholic and nonalcoholic male subjects with different body compositions, through pharmacokinetics of chlorzoxazone (CLZ). We also intended to study the relationship between CLZ hydroxylation and urinary levels of 8-hydroxydiguanosine, and between CLZ levels and liver histology.Serial measurements of CLZ serum concentration, after a 750 mg dose, were performed in 17 alcoholics (9 normal weight and 8 obese) and 21 nonalcoholic subjects (10 normal weight and 11 obese). Concentration of 6-hydroxy-chlorzoxazone (6-OH-CLZ) was determined at the second hour. Anthropometry, clinical laboratory tests, and urinary 8-hydroxydiguanosine concentrations were measured. Liver biopsies were performed in alcoholics.Five biopsies revealed severe lesions, one in normal-weight and four in obese patients (p = NS). Area under the curve (AUC) of CLZ was higher in normal-weight controls compared with the rest of the groups (ANOVA p = 0.001). This parameter correlated negatively with adiposity in nonalcoholic subjects and did not correlate with liver histology. 6-OH-CLZ/CLZ ratio was lower in normal-weight controls, compared with obese subjects and normal-weight alcoholics (p = 0.02). Both alcoholism and obesity were included as predictors of CLZ AUC in a multiple regression analysis. The two-factor ANOVA showed an additive effect of centripetal body fat distribution and alcoholism. Urinary 8-hydroxydiguanosine levels were extremely variable.Centripetal adiposity and alcoholism are associated with induction of CYP2E1. This may explain the higher prevalence of liver damage among obese alcoholics and also nonalcoholic steatohepatitis." @default.
- W2073789511 created "2016-06-24" @default.
- W2073789511 creator A5002372335 @default.
- W2073789511 creator A5029521312 @default.
- W2073789511 creator A5035007159 @default.
- W2073789511 creator A5046342211 @default.
- W2073789511 creator A5051612804 @default.
- W2073789511 creator A5058111785 @default.
- W2073789511 date "2000-05-01" @default.
- W2073789511 modified "2023-09-27" @default.
- W2073789511 title "Changes in Microsomal Activity in Alcoholism and Obesity" @default.
- W2073789511 cites W1539472548 @default.
- W2073789511 cites W1827616259 @default.
- W2073789511 cites W1901566088 @default.
- W2073789511 cites W1967712749 @default.
- W2073789511 cites W1968209245 @default.
- W2073789511 cites W1968384463 @default.
- W2073789511 cites W1968946461 @default.
- W2073789511 cites W1975628073 @default.
- W2073789511 cites W1978135825 @default.
- W2073789511 cites W1987296974 @default.
- W2073789511 cites W1988292500 @default.
- W2073789511 cites W1991423707 @default.
- W2073789511 cites W1992058399 @default.
- W2073789511 cites W1992230920 @default.
- W2073789511 cites W2002630124 @default.
- W2073789511 cites W2006317094 @default.
- W2073789511 cites W2009753741 @default.
- W2073789511 cites W2012591813 @default.
- W2073789511 cites W2016411116 @default.
- W2073789511 cites W2019372384 @default.
- W2073789511 cites W2020267550 @default.
- W2073789511 cites W2022689643 @default.
- W2073789511 cites W2024537358 @default.
- W2073789511 cites W2031677322 @default.
- W2073789511 cites W2036342079 @default.
- W2073789511 cites W2049849453 @default.
- W2073789511 cites W2050045343 @default.
- W2073789511 cites W2053026149 @default.
- W2073789511 cites W2054133295 @default.
- W2073789511 cites W2058709707 @default.
- W2073789511 cites W2068520436 @default.
- W2073789511 cites W2069007287 @default.
- W2073789511 cites W2071663651 @default.
- W2073789511 cites W2072244763 @default.
- W2073789511 cites W2074890352 @default.
- W2073789511 cites W2083152621 @default.
- W2073789511 cites W2083676370 @default.
- W2073789511 cites W2083946590 @default.
- W2073789511 cites W2086501877 @default.
- W2073789511 cites W2094245622 @default.
- W2073789511 cites W2123650181 @default.
- W2073789511 cites W2130694306 @default.
- W2073789511 cites W2133406706 @default.
- W2073789511 cites W2183591749 @default.
- W2073789511 cites W2409351816 @default.
- W2073789511 cites W2413366353 @default.
- W2073789511 cites W3021700502 @default.
- W2073789511 doi "https://doi.org/10.1097/00000374-200005000-00004" @default.
- W2073789511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10832901" @default.
- W2073789511 hasPublicationYear "2000" @default.
- W2073789511 type Work @default.
- W2073789511 sameAs 2073789511 @default.
- W2073789511 citedByCount "10" @default.
- W2073789511 crossrefType "journal-article" @default.
- W2073789511 hasAuthorship W2073789511A5002372335 @default.
- W2073789511 hasAuthorship W2073789511A5029521312 @default.
- W2073789511 hasAuthorship W2073789511A5035007159 @default.
- W2073789511 hasAuthorship W2073789511A5046342211 @default.
- W2073789511 hasAuthorship W2073789511A5051612804 @default.
- W2073789511 hasAuthorship W2073789511A5058111785 @default.
- W2073789511 hasConcept C126322002 @default.
- W2073789511 hasConcept C134018914 @default.
- W2073789511 hasConcept C511355011 @default.
- W2073789511 hasConcept C71924100 @default.
- W2073789511 hasConcept C90924648 @default.
- W2073789511 hasConcept C99476002 @default.
- W2073789511 hasConceptScore W2073789511C126322002 @default.
- W2073789511 hasConceptScore W2073789511C134018914 @default.
- W2073789511 hasConceptScore W2073789511C511355011 @default.
- W2073789511 hasConceptScore W2073789511C71924100 @default.
- W2073789511 hasConceptScore W2073789511C90924648 @default.
- W2073789511 hasConceptScore W2073789511C99476002 @default.
- W2073789511 hasIssue "5" @default.
- W2073789511 hasLocation W20737895111 @default.
- W2073789511 hasLocation W20737895112 @default.
- W2073789511 hasOpenAccess W2073789511 @default.
- W2073789511 hasPrimaryLocation W20737895111 @default.
- W2073789511 hasRelatedWork W1966504330 @default.
- W2073789511 hasRelatedWork W1966775726 @default.
- W2073789511 hasRelatedWork W1974041167 @default.
- W2073789511 hasRelatedWork W1979139803 @default.
- W2073789511 hasRelatedWork W2030889776 @default.
- W2073789511 hasRelatedWork W2037631372 @default.
- W2073789511 hasRelatedWork W2040058909 @default.
- W2073789511 hasRelatedWork W2132898409 @default.
- W2073789511 hasRelatedWork W2748952813 @default.
- W2073789511 hasRelatedWork W4249176446 @default.