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• W2073796806 abstract "Purpose of review: Bone mineralization is a tightly regulated process. The whole molecular machinery responsible for the initial formation of chemically defined and spatially ordered crystals of calcium phosphate, hydroxyapatite, is located in the matrix vesicles released into the extracellular matrix by calcifying bone osteoblasts or embryonic and growth plate cartilage hypertrophic chondrocytes. The review will focus on the dual roles of extracellular ATP in the regulation of the initial steps of mineralization. Recent findings: Extracellular ATP is involved in the regulation of bone and cartilage metabolism, acting via receptors for purines and pyrimidines with ATP, ADP, UTP and UDP as ligands on osteoblasts, osteoclasts and chondrocytes. New findings indicated that ATP can affect the mineral type formed in matrix vesicles, harboring ATP-hydrolyzing enzymes, such as tissue-nonspecific alkaline phosphatase and nucleotide triphosphate pyrophosphatase phosphodiesterase isoform 1, producing effectors of mineralization, stimulatory inorganic phosphate or inhibitory inorganic pyrophosphate. These finding have a potentially significant impact on the understanding of the molecular mechanisms of physiological and pathological mineralization. Summary: The regulatory functions of ATP in mineralization extend its role beyond a universal ‘high-energy’ compound and signaling molecule. In addition, the findings prompted searching for new target proteins implicated in mineralization as revealed by a recent proteome analysis of matrix vesicles." @default.
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• W2073796806 date "2007-09-01" @default.
• W2073796806 modified "2023-09-25" @default.
• W2073796806 title "Extracellular ATP and its effects on physiological and pathological mineralization" @default.
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• W2073796806 doi "https://doi.org/10.1097/bco.0b013e328285dfe8" @default.
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