Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073815649> ?p ?o ?g. }
- W2073815649 endingPage "e66810" @default.
- W2073815649 startingPage "e66810" @default.
- W2073815649 abstract "Motor impairment is highly prevalent in HIV-infected patients. Here, we assess associations between peripheral muscular deficits as evaluated by the 5 sit-to-stand test (5STS) and structural integrity of the motor system at a central level. Eighty-six HIV-infected patients receiving combination antiretroviral therapy and with no major cerebral events, underwent an MRI scan and the 5STS. Out of 86 participants, forty presented a score greater than two standard deviations above mean normative scores calculated for the 5STS and were therefore considered as motor-impaired. MRI-structural cerebral parameters were compared to the unimpaired participants. Fractional Anisotropy (FA), Axial Diffusivity (AD) and Radial Diffusivity (RD), reflecting microstructural integrity, were extracted from Diffusion-Tensor MRI. Global and regional cerebral volumes or thicknesses were extracted from 3D-T1 morphological MRI. Whereas the two groups did not differ for any HIV variables, voxel-wise analysis revealed that motor-impaired participants present low FA values in various cortico-motor tracts and low AD in left cortico-spinal tract. However, they did not present reduced volumes or thicknesses of the precentral cortices compared to unimpaired participants. The absence of alterations in cortical regions holding motor-neurons might argue against neurodegenerative process as an explanation of White Matter (WM) disorganization." @default.
- W2073815649 created "2016-06-24" @default.
- W2073815649 creator A5026011138 @default.
- W2073815649 creator A5044191666 @default.
- W2073815649 creator A5048433739 @default.
- W2073815649 creator A5050282699 @default.
- W2073815649 creator A5063746447 @default.
- W2073815649 creator A5066723376 @default.
- W2073815649 creator A5066848773 @default.
- W2073815649 creator A5067996191 @default.
- W2073815649 creator A5080050550 @default.
- W2073815649 date "2013-07-11" @default.
- W2073815649 modified "2023-10-16" @default.
- W2073815649 title "Muscular Weakness in Individuals with HIV Associated with a Disorganization of the Cortico-Spinal Tract: A Multi-Modal MRI Investigation" @default.
- W2073815649 cites W1823672047 @default.
- W2073815649 cites W1963526785 @default.
- W2073815649 cites W1964565539 @default.
- W2073815649 cites W1974477598 @default.
- W2073815649 cites W1981202009 @default.
- W2073815649 cites W1981440793 @default.
- W2073815649 cites W1981453697 @default.
- W2073815649 cites W1981613901 @default.
- W2073815649 cites W1981734795 @default.
- W2073815649 cites W1984114761 @default.
- W2073815649 cites W1984677038 @default.
- W2073815649 cites W1985519018 @default.
- W2073815649 cites W1985773590 @default.
- W2073815649 cites W1988279296 @default.
- W2073815649 cites W1994135183 @default.
- W2073815649 cites W1997749719 @default.
- W2073815649 cites W1999253999 @default.
- W2073815649 cites W2002665706 @default.
- W2073815649 cites W2004293194 @default.
- W2073815649 cites W2004348670 @default.
- W2073815649 cites W2005495240 @default.
- W2073815649 cites W2008655880 @default.
- W2073815649 cites W2009518075 @default.
- W2073815649 cites W2022781987 @default.
- W2073815649 cites W2025047388 @default.
- W2073815649 cites W2027328104 @default.
- W2073815649 cites W2029436652 @default.
- W2073815649 cites W2038355611 @default.
- W2073815649 cites W2038470102 @default.
- W2073815649 cites W2042673904 @default.
- W2073815649 cites W2044282009 @default.
- W2073815649 cites W2047152236 @default.
- W2073815649 cites W2053611092 @default.
- W2073815649 cites W2059540227 @default.
- W2073815649 cites W2063001897 @default.
- W2073815649 cites W2068386340 @default.
- W2073815649 cites W2077108850 @default.
- W2073815649 cites W2079228607 @default.
- W2073815649 cites W2079456245 @default.
- W2073815649 cites W2091931051 @default.
- W2073815649 cites W2092539348 @default.
- W2073815649 cites W2095446662 @default.
- W2073815649 cites W2101135654 @default.
- W2073815649 cites W2101146082 @default.
- W2073815649 cites W2103224749 @default.
- W2073815649 cites W2105890305 @default.
- W2073815649 cites W2106319887 @default.
- W2073815649 cites W2108588467 @default.
- W2073815649 cites W2109227767 @default.
- W2073815649 cites W2109951107 @default.
- W2073815649 cites W2110208125 @default.
- W2073815649 cites W2110437310 @default.
- W2073815649 cites W2118421222 @default.
- W2073815649 cites W2119848633 @default.
- W2073815649 cites W2121369614 @default.
- W2073815649 cites W2122190417 @default.
- W2073815649 cites W2126449827 @default.
- W2073815649 cites W2137984639 @default.
- W2073815649 cites W2139158372 @default.
- W2073815649 cites W2142255966 @default.
- W2073815649 cites W2143697404 @default.
- W2073815649 cites W2145500340 @default.
- W2073815649 cites W2148360587 @default.
- W2073815649 cites W2150667092 @default.
- W2073815649 cites W2151130155 @default.
- W2073815649 cites W2151721316 @default.
- W2073815649 cites W2152868092 @default.
- W2073815649 cites W2157270343 @default.
- W2073815649 cites W2157649211 @default.
- W2073815649 cites W2162723250 @default.
- W2073815649 cites W2163420873 @default.
- W2073815649 cites W2165468207 @default.
- W2073815649 cites W2169005238 @default.
- W2073815649 cites W2169211575 @default.
- W2073815649 cites W2169229980 @default.
- W2073815649 cites W2316138036 @default.
- W2073815649 cites W4293234668 @default.
- W2073815649 doi "https://doi.org/10.1371/journal.pone.0066810" @default.
- W2073815649 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3708953" @default.
- W2073815649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23874398" @default.
- W2073815649 hasPublicationYear "2013" @default.
- W2073815649 type Work @default.
- W2073815649 sameAs 2073815649 @default.
- W2073815649 citedByCount "8" @default.