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• W2073817698 startingPage "3046" @default.
• W2073817698 abstract "Cyclin-dependent kinase inhibitors (CKIs) play key roles in controlling the eukaryotic cell cycle by coordinating cell proliferation and differentiation. Understanding the roles of CKIs requires knowledge of how they are regulated both through the cell cycle and in response to extracellular signals. Here we show that the yeast CKI, Far1p, is controlled by ubiquitin-dependent proteolysis. Wild-type Far1p was stable only in the G 1 phase of the cell cycle. Biochemical and genetic evidence indicate that its degradation required the components of the G 1 –S ubiquitination system, Cdc34p, Cdc4p, Cdc53p, and Skp1p. We isolated a mutant form of Far1p (Far1p-22) that was able to induce cell cycle arrest in the absence of α-factor. Cells that overexpress Far1-22p arrested in G 1 as large unbudded cells with low Cdc28p–Clnp kinase activity. Wild-type Far1p, but not Far1-22p, was readily ubiquitinated in vitro in a CDC34 - and CDC4 -dependent manner. Far1-22p harbors a single amino acid change, from serine to proline at residue 87, which alters phosphorylation by Cdc28p–Cln2p in vitro. Our results show that Far1p is regulated by ubiquitin-mediated proteolysis and suggest that phosphorylation of Far1p by the Cdc28p–Clnp kinase is part of the recognition signal for ubiquitination." @default.
• W2073817698 created "2016-06-24" @default.
• W2073817698 creator A5033986178 @default.
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• W2073817698 creator A5067556728 @default.
• W2073817698 creator A5080958654 @default.
• W2073817698 date "1997-11-15" @default.
• W2073817698 modified "2023-10-14" @default.
• W2073817698 title "Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast" @default.
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• W2073817698 cites W1540566915 @default.
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• W2073817698 cites W1610736862 @default.
• W2073817698 cites W1964827998 @default.
• W2073817698 cites W1967071341 @default.
• W2073817698 cites W1968606500 @default.
• W2073817698 cites W1973122477 @default.
• W2073817698 cites W1973782344 @default.
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• W2073817698 cites W1977501998 @default.
• W2073817698 cites W1977868902 @default.
• W2073817698 cites W1978186903 @default.
• W2073817698 cites W1980073547 @default.
• W2073817698 cites W1980123375 @default.
• W2073817698 cites W1980720313 @default.
• W2073817698 cites W1993983676 @default.
• W2073817698 cites W1994066190 @default.
• W2073817698 cites W1994523623 @default.
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• W2073817698 cites W2039839254 @default.
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• W2073817698 cites W2049366728 @default.
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• W2073817698 doi "https://doi.org/10.1101/gad.11.22.3046" @default.
• W2073817698 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/316705" @default.
• W2073817698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9367986" @default.
• W2073817698 hasPublicationYear "1997" @default.
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