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- W2073838981 abstract "The analgesic effect f β-lipotropin /β -LPH/ and its fragments administered intracerebroventricularly /ICV/ to rats was studied. β -LPH proved to be a specific, morphine-like analgesic possesing 2.2 times weaker analgesic potency than morphine, calculated on molar base. Tryptic digest of β -LPH or smaller fragments of the hormone /LPH-/61 2 65/-eptide and LPH-/61–69/-peptide/ were devoid of significant analgesic activity. The in vivo results appeared to be in contrast to those previously obtained in longitudinal muscle strip of guinea-pig ileum, in vitro. A tentative explanation of this apparent contradiction is also given." @default.
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- W2073838981 date "1976-09-01" @default.
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- W2073838981 title "Morphine-like analgesic effect of a pituitary hormone, β-lipotropin" @default.
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- W2073838981 doi "https://doi.org/10.1016/0024-3205(76)90171-5" @default.
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