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• W2073841658 startingPage "228" @default.
• W2073841658 abstract "Human immunodeficiency virus (HIV) infection is associated with the loss of the two principal types of dendritic cell (DC), myeloid DC (mDC) and plasmacytoid DC (pDC), but the mechanism of this loss and its relationship to AIDS pathogenesis remain ill-defined. The nonhuman primate is a powerful model to dissect this response for several reasons. Both DC subsets have been well characterized in nonhuman primates and shown to have strikingly similar phenotypic and functional characteristics to their counterparts in the human. Moreover, decline of mDC and pDC occurs in rhesus macaques with end-stage simian immunodeficiency virus (SIV) infection, the model of HIV infection in humans. In this brief review, we discuss what is known about DC subsets in pathogenic and nonpathogenic nonhuman primate models of HIV infection and highlight the advances and controversies that currently exist in the field." @default.
• W2073841658 created "2016-06-24" @default.
• W2073841658 creator A5014745182 @default.
• W2073841658 creator A5031665739 @default.
• W2073841658 creator A5046510431 @default.
• W2073841658 creator A5078044363 @default.
• W2073841658 date "2011-06-30" @default.
• W2073841658 modified "2023-09-26" @default.
• W2073841658 title "Dissecting the role of dendritic cells in simian immunodeficiency virus infection and AIDS" @default.
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