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• W2073842854 abstract "ObjectiveIn order to determine the impact of high serum progesterone level on hCG administration day on human endometrial receptivity, we compared the gene expression endometrial shift during the pre-receptive vs. receptive stage according to the progesterone level.DesignEndometrial biopsies have been performed during oocytes collection day (hCG+2) and receptive (hCG+5) phase in the same patients (n=10) under controlled ovarian stimulation. Gene expression profile shift between hCG+2 and hCG+5 stages were analyzed according to progesterone serum level on hCG day (group A: [P] < 1.5 ng/mL; group B: [P] > 1.5 ng/mL).Materials and MethodsFor each normal responder patients, 2 endometrail biopsies were performed and mRNAs were extracted. Gene expression profiles were analyzed by DNA microarray chips.ResultsIn the group A, we identified 1477 genes differentially expressed between the hCG+2 and hCG+5 samples including 877 up- and 600 down-regulated genes (FDR<0.05, fold change >2), corresponding to the typical transcriptomic shift signature. In contrast, only 233 genes (123 up, 110 down) were differentially expressed between the two endometrial sample groups in the group B. The cross-intersection of the two lists of genes (groups A and B) revealed that there were 212 genes (111 up, 101 down) exclusive to the high serum progesterone level. Among them, there were several genes associated to the cell cycle function [(CCNB1 (x-2.1), CCNB2 (x-2.1), CHEK1 (-2.1), CDC25C (-2.1) and E2F7 (x-2.2)] which were all down-regulated.ConclusionThe gene expression profiles of the endometrial shift from the pre-receptive and receptive stage is altered in patients with high serum progesterone level on hCG administration day. This alteration suggests an advancement of endometrial maturation and can explain the lower pregnancy rate observed in the presence of elevated progesterone. By this way, systematic fresh embryo replacement should be reconsidered. ObjectiveIn order to determine the impact of high serum progesterone level on hCG administration day on human endometrial receptivity, we compared the gene expression endometrial shift during the pre-receptive vs. receptive stage according to the progesterone level. In order to determine the impact of high serum progesterone level on hCG administration day on human endometrial receptivity, we compared the gene expression endometrial shift during the pre-receptive vs. receptive stage according to the progesterone level. DesignEndometrial biopsies have been performed during oocytes collection day (hCG+2) and receptive (hCG+5) phase in the same patients (n=10) under controlled ovarian stimulation. Gene expression profile shift between hCG+2 and hCG+5 stages were analyzed according to progesterone serum level on hCG day (group A: [P] < 1.5 ng/mL; group B: [P] > 1.5 ng/mL). Endometrial biopsies have been performed during oocytes collection day (hCG+2) and receptive (hCG+5) phase in the same patients (n=10) under controlled ovarian stimulation. Gene expression profile shift between hCG+2 and hCG+5 stages were analyzed according to progesterone serum level on hCG day (group A: [P] < 1.5 ng/mL; group B: [P] > 1.5 ng/mL). Materials and MethodsFor each normal responder patients, 2 endometrail biopsies were performed and mRNAs were extracted. Gene expression profiles were analyzed by DNA microarray chips. For each normal responder patients, 2 endometrail biopsies were performed and mRNAs were extracted. Gene expression profiles were analyzed by DNA microarray chips. ResultsIn the group A, we identified 1477 genes differentially expressed between the hCG+2 and hCG+5 samples including 877 up- and 600 down-regulated genes (FDR<0.05, fold change >2), corresponding to the typical transcriptomic shift signature. In contrast, only 233 genes (123 up, 110 down) were differentially expressed between the two endometrial sample groups in the group B. The cross-intersection of the two lists of genes (groups A and B) revealed that there were 212 genes (111 up, 101 down) exclusive to the high serum progesterone level. Among them, there were several genes associated to the cell cycle function [(CCNB1 (x-2.1), CCNB2 (x-2.1), CHEK1 (-2.1), CDC25C (-2.1) and E2F7 (x-2.2)] which were all down-regulated. In the group A, we identified 1477 genes differentially expressed between the hCG+2 and hCG+5 samples including 877 up- and 600 down-regulated genes (FDR<0.05, fold change >2), corresponding to the typical transcriptomic shift signature. In contrast, only 233 genes (123 up, 110 down) were differentially expressed between the two endometrial sample groups in the group B. The cross-intersection of the two lists of genes (groups A and B) revealed that there were 212 genes (111 up, 101 down) exclusive to the high serum progesterone level. Among them, there were several genes associated to the cell cycle function [(CCNB1 (x-2.1), CCNB2 (x-2.1), CHEK1 (-2.1), CDC25C (-2.1) and E2F7 (x-2.2)] which were all down-regulated. ConclusionThe gene expression profiles of the endometrial shift from the pre-receptive and receptive stage is altered in patients with high serum progesterone level on hCG administration day. This alteration suggests an advancement of endometrial maturation and can explain the lower pregnancy rate observed in the presence of elevated progesterone. By this way, systematic fresh embryo replacement should be reconsidered. The gene expression profiles of the endometrial shift from the pre-receptive and receptive stage is altered in patients with high serum progesterone level on hCG administration day. This alteration suggests an advancement of endometrial maturation and can explain the lower pregnancy rate observed in the presence of elevated progesterone. By this way, systematic fresh embryo replacement should be reconsidered." @default.
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• W2073842854 date "2012-09-01" @default.
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• W2073842854 title "High progesterone level on hCG day impairs gene expression profile shift between pre-receptive and receptive secretory phase of endometrial cells" @default.
• W2073842854 doi "https://doi.org/10.1016/j.fertnstert.2012.07.821" @default.
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