Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073846095> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2073846095 endingPage "1007" @default.
- W2073846095 startingPage "997" @default.
- W2073846095 abstract "X-ray diffraction patterns from human arterial specimens containing atherosclerotic fatty streak lesions exhibited a single sharp reflection, corresponding to a structural spacing of about 35 A. Specimens without lesions did not. When specimens with fatty streaks were heated, an order-to-disorder phase transition was revealed by the disappearance of the sharp reflection. The transition was thermally reversible and its temperature varied from aorta to aorta over a range from 28 degrees to 42 degrees C. Since cholesteryl ester droplets are a major component of fatty streaks, comparison studies were made of the diffraction behavior from pure cholesteryl esters. We found that the diffraction patterns of the fatty streak material could be accounted for by the organization of the cholesteryl esters into a liquid-crystalline smectic phase that melts from the smectic to a less ordered phase upon heating. When combined with the conclusions of others from polarized light microscopy, our study shows that a droplet in the smectic phase has well-defined concentric layers of lipid molecules. In each layer, the long axes of the molecules have a net radial orientation with respect to the droplet, but the side-to-side organization is disordered. We suggest that the accessibility of portions of the lipids for specific binding to enzymes or transport proteins may be restricted when they are in the smectic state, and that exchange of lipids with surrounding membranes or other potential binding sites may likewise be inhibited. The restriction in the smectic phase should be greater than in the less ordered phases that exist at higher temperatures." @default.
- W2073846095 created "2016-06-24" @default.
- W2073846095 creator A5002753770 @default.
- W2073846095 creator A5022027071 @default.
- W2073846095 date "1976-10-01" @default.
- W2073846095 modified "2023-10-18" @default.
- W2073846095 title "Molecular organization of the cholesteryl ester droplets in the fatty streaks of human aorta." @default.
- W2073846095 cites W1481073504 @default.
- W2073846095 cites W1532082124 @default.
- W2073846095 cites W2004727716 @default.
- W2073846095 cites W2017379515 @default.
- W2073846095 cites W2081562088 @default.
- W2073846095 cites W2087595306 @default.
- W2073846095 cites W2118747321 @default.
- W2073846095 cites W2417411666 @default.
- W2073846095 cites W33670486 @default.
- W2073846095 doi "https://doi.org/10.1172/jci108554" @default.
- W2073846095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/333264" @default.
- W2073846095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/965500" @default.
- W2073846095 hasPublicationYear "1976" @default.
- W2073846095 type Work @default.
- W2073846095 sameAs 2073846095 @default.
- W2073846095 citedByCount "32" @default.
- W2073846095 countsByYear W20738460952014 @default.
- W2073846095 countsByYear W20738460952019 @default.
- W2073846095 countsByYear W20738460952020 @default.
- W2073846095 countsByYear W20738460952021 @default.
- W2073846095 countsByYear W20738460952022 @default.
- W2073846095 countsByYear W20738460952023 @default.
- W2073846095 crossrefType "journal-article" @default.
- W2073846095 hasAuthorship W2073846095A5002753770 @default.
- W2073846095 hasAuthorship W2073846095A5022027071 @default.
- W2073846095 hasBestOaLocation W20738460951 @default.
- W2073846095 hasConcept C120665830 @default.
- W2073846095 hasConcept C121332964 @default.
- W2073846095 hasConcept C12554922 @default.
- W2073846095 hasConcept C149288129 @default.
- W2073846095 hasConcept C178790620 @default.
- W2073846095 hasConcept C185592680 @default.
- W2073846095 hasConcept C192562407 @default.
- W2073846095 hasConcept C199289684 @default.
- W2073846095 hasConcept C207114421 @default.
- W2073846095 hasConcept C2776448209 @default.
- W2073846095 hasConcept C2778116356 @default.
- W2073846095 hasConcept C2778163477 @default.
- W2073846095 hasConcept C2780072125 @default.
- W2073846095 hasConcept C32909587 @default.
- W2073846095 hasConcept C44280652 @default.
- W2073846095 hasConcept C55493867 @default.
- W2073846095 hasConcept C62520636 @default.
- W2073846095 hasConcept C65185188 @default.
- W2073846095 hasConcept C8010536 @default.
- W2073846095 hasConcept C86803240 @default.
- W2073846095 hasConceptScore W2073846095C120665830 @default.
- W2073846095 hasConceptScore W2073846095C121332964 @default.
- W2073846095 hasConceptScore W2073846095C12554922 @default.
- W2073846095 hasConceptScore W2073846095C149288129 @default.
- W2073846095 hasConceptScore W2073846095C178790620 @default.
- W2073846095 hasConceptScore W2073846095C185592680 @default.
- W2073846095 hasConceptScore W2073846095C192562407 @default.
- W2073846095 hasConceptScore W2073846095C199289684 @default.
- W2073846095 hasConceptScore W2073846095C207114421 @default.
- W2073846095 hasConceptScore W2073846095C2776448209 @default.
- W2073846095 hasConceptScore W2073846095C2778116356 @default.
- W2073846095 hasConceptScore W2073846095C2778163477 @default.
- W2073846095 hasConceptScore W2073846095C2780072125 @default.
- W2073846095 hasConceptScore W2073846095C32909587 @default.
- W2073846095 hasConceptScore W2073846095C44280652 @default.
- W2073846095 hasConceptScore W2073846095C55493867 @default.
- W2073846095 hasConceptScore W2073846095C62520636 @default.
- W2073846095 hasConceptScore W2073846095C65185188 @default.
- W2073846095 hasConceptScore W2073846095C8010536 @default.
- W2073846095 hasConceptScore W2073846095C86803240 @default.
- W2073846095 hasIssue "4" @default.
- W2073846095 hasLocation W20738460951 @default.
- W2073846095 hasLocation W20738460952 @default.
- W2073846095 hasLocation W20738460953 @default.
- W2073846095 hasLocation W20738460954 @default.
- W2073846095 hasLocation W20738460955 @default.
- W2073846095 hasOpenAccess W2073846095 @default.
- W2073846095 hasPrimaryLocation W20738460951 @default.
- W2073846095 hasRelatedWork W1967781820 @default.
- W2073846095 hasRelatedWork W2032483264 @default.
- W2073846095 hasRelatedWork W2044422388 @default.
- W2073846095 hasRelatedWork W2046269024 @default.
- W2073846095 hasRelatedWork W2062309494 @default.
- W2073846095 hasRelatedWork W2073846095 @default.
- W2073846095 hasRelatedWork W2085083082 @default.
- W2073846095 hasRelatedWork W2618343058 @default.
- W2073846095 hasRelatedWork W2952325823 @default.
- W2073846095 hasRelatedWork W33670486 @default.
- W2073846095 hasVolume "58" @default.
- W2073846095 isParatext "false" @default.
- W2073846095 isRetracted "false" @default.
- W2073846095 magId "2073846095" @default.
- W2073846095 workType "article" @default.