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• W2073847757 abstract "Mice with targeted deletion of the GABA catabolic enzyme succinic semialdehyde dehydrogenase (SSADH) manifest lethal tonic-clonic seizures, amenable to pharmacologic rescue, at 3-4 weeks of life. In the current report, we characterized amino acid profiles in SSADH(-/-) brain utilizing whole brain and regional extracts (frontal and parietal cortex, hippocampus, and cerebellum) to develop hypotheses concerning epileptogenesis. Of 35 amino acids quantified, we found significant dysregulation in SSADH(-/-) mice for 11 (GABA, glutamate, glutamine, alanine, aspartate, serine, taurine, cystathionine, methionine, homocarnosine, and arginine) as compared to age-matched littermates both before, and following, the period of generalized convulsive seizures and status epilepticus. Our results reveal imbalanced amino acid levels potentially involved in the transition from absence seizures to generalized convulsive seizures resulting in SSADH(-/-) mice. We conclude that the SSADH(-/-) mouse represents a unique epileptic model with the potential to reveal novel aspects of excitatory/inhibitory interactions in the genesis of seizures." @default.
• W2073847757 created "2016-06-24" @default.
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• W2073847757 date "2004-08-01" @default.
• W2073847757 modified "2023-10-18" @default.
• W2073847757 title "Seizure evolution and amino acid imbalances in murine succinate semialdehyde dehydrogenase (SSADH) deficiency" @default.
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• W2073847757 doi "https://doi.org/10.1016/j.nbd.2004.04.008" @default.
• W2073847757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15262267" @default.
• W2073847757 hasPublicationYear "2004" @default.
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