FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073851790> ?p ?o ?g. }

• W2073851790 endingPage "35" @default.
• W2073851790 startingPage "27" @default.
• W2073851790 abstract "The vertebrate calmodulin is configured with two structurally independent globular lobes in N- and C-terminus, and a flexible central linker. Distinctly, two lobes of calmodulin from Saccharomyces cerevisiae (yCaM) interact and influence the Ca(2+)-binding profile of each other. We explored this further using the mutant proteins with eliminated Ca(2+)-binding ability in one of the lobes and found that the Ca(2+)-bound N-lobe associates with the Ca(2+)-free C-lobe to gain the Ca(2+) affinity of a wild-type level. Next, analysing series of C-terminal residue truncation mutant, we found that the truncation of C-terminal three residues induce the hyper Ca(2+) affinity. These residues are also important for the general structural behaviour of calmodulin, such as Ca(2+)-induced slow mobility shift in polyacrylamide gel electrophoresis and for the ability to activate Cmk1p (yeast calmodulin kinase). These suggest: (i) when Ca(2+) occupies only N-lobe, two lobes interact and form the stable intermediate leading to a proper level of Ca(2+) affinity; (ii) the C-terminal three residues are required to prohibit abnormal stabilization of the intermediate promoting abnormally high Ca(2+) affinity and for recognition of target enzymes. A model for Ca(2+) and target bindings of yCaM is proposed. Evolutional aspect concerning the biological significance of this model was discussed." @default.
• W2073851790 created "2016-06-24" @default.
• W2073851790 creator A5010975602 @default.
• W2073851790 creator A5011376842 @default.
• W2073851790 creator A5024274003 @default.
• W2073851790 creator A5068941563 @default.
• W2073851790 date "2012-05-04" @default.
• W2073851790 modified "2023-09-23" @default.
• W2073851790 title "Specific conformation and Ca2+-binding mode of yeast calmodulin: insight into evolutionary development" @default.
• W2073851790 cites W1876704297 @default.
• W2073851790 cites W1894512944 @default.
• W2073851790 cites W1936097558 @default.
• W2073851790 cites W1967897161 @default.
• W2073851790 cites W1987159249 @default.
• W2073851790 cites W1987312402 @default.
• W2073851790 cites W1991925949 @default.
• W2073851790 cites W1992140809 @default.
• W2073851790 cites W1992877333 @default.
• W2073851790 cites W1998604110 @default.
• W2073851790 cites W2009713636 @default.
• W2073851790 cites W2010420138 @default.
• W2073851790 cites W2024142216 @default.
• W2073851790 cites W2029414149 @default.
• W2073851790 cites W2029870632 @default.
• W2073851790 cites W2031811477 @default.
• W2073851790 cites W2044091418 @default.
• W2073851790 cites W2046522192 @default.
• W2073851790 cites W2048182456 @default.
• W2073851790 cites W2059873058 @default.
• W2073851790 cites W2069187446 @default.
• W2073851790 cites W2075135679 @default.
• W2073851790 cites W2075659345 @default.
• W2073851790 cites W2093695208 @default.
• W2073851790 cites W2119218083 @default.
• W2073851790 cites W2155481300 @default.
• W2073851790 cites W2440125231 @default.
• W2073851790 cites W84630131 @default.
• W2073851790 doi "https://doi.org/10.1093/jb/mvs048" @default.
• W2073851790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22563102" @default.
• W2073851790 hasPublicationYear "2012" @default.
• W2073851790 type Work @default.
• W2073851790 sameAs 2073851790 @default.
• W2073851790 citedByCount "2" @default.
• W2073851790 countsByYear W20738517902016 @default.
• W2073851790 countsByYear W20738517902022 @default.
• W2073851790 crossrefType "journal-article" @default.
• W2073851790 hasAuthorship W2073851790A5010975602 @default.
• W2073851790 hasAuthorship W2073851790A5011376842 @default.
• W2073851790 hasAuthorship W2073851790A5024274003 @default.
• W2073851790 hasAuthorship W2073851790A5068941563 @default.
• W2073851790 hasConcept C104317684 @default.
• W2073851790 hasConcept C107824862 @default.
• W2073851790 hasConcept C111919701 @default.
• W2073851790 hasConcept C12554922 @default.
• W2073851790 hasConcept C143065580 @default.
• W2073851790 hasConcept C178790620 @default.
• W2073851790 hasConcept C181199279 @default.
• W2073851790 hasConcept C185592680 @default.
• W2073851790 hasConcept C2777576037 @default.
• W2073851790 hasConcept C2779222958 @default.
• W2073851790 hasConcept C2780557392 @default.
• W2073851790 hasConcept C29688787 @default.
• W2073851790 hasConcept C41008148 @default.
• W2073851790 hasConcept C519063684 @default.
• W2073851790 hasConcept C55493867 @default.
• W2073851790 hasConcept C71240020 @default.
• W2073851790 hasConcept C86803240 @default.
• W2073851790 hasConceptScore W2073851790C104317684 @default.
• W2073851790 hasConceptScore W2073851790C107824862 @default.
• W2073851790 hasConceptScore W2073851790C111919701 @default.
• W2073851790 hasConceptScore W2073851790C12554922 @default.
• W2073851790 hasConceptScore W2073851790C143065580 @default.
• W2073851790 hasConceptScore W2073851790C178790620 @default.
• W2073851790 hasConceptScore W2073851790C181199279 @default.
• W2073851790 hasConceptScore W2073851790C185592680 @default.
• W2073851790 hasConceptScore W2073851790C2777576037 @default.
• W2073851790 hasConceptScore W2073851790C2779222958 @default.
• W2073851790 hasConceptScore W2073851790C2780557392 @default.
• W2073851790 hasConceptScore W2073851790C29688787 @default.
• W2073851790 hasConceptScore W2073851790C41008148 @default.
• W2073851790 hasConceptScore W2073851790C519063684 @default.
• W2073851790 hasConceptScore W2073851790C55493867 @default.
• W2073851790 hasConceptScore W2073851790C71240020 @default.
• W2073851790 hasConceptScore W2073851790C86803240 @default.
• W2073851790 hasIssue "1" @default.
• W2073851790 hasLocation W20738517901 @default.
• W2073851790 hasLocation W20738517902 @default.
• W2073851790 hasOpenAccess W2073851790 @default.
• W2073851790 hasPrimaryLocation W20738517901 @default.
• W2073851790 hasRelatedWork W1520817266 @default.
• W2073851790 hasRelatedWork W1982584572 @default.
• W2073851790 hasRelatedWork W2056142580 @default.
• W2073851790 hasRelatedWork W2072731694 @default.
• W2073851790 hasRelatedWork W2081690701 @default.
• W2073851790 hasRelatedWork W2090094492 @default.
• W2073851790 hasRelatedWork W2094041192 @default.
• W2073851790 hasRelatedWork W2418152545 @default.
• W2073851790 hasRelatedWork W3120238434 @default.

• next