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- W2073865764 abstract "Scope Ochratoxin A ( OTA ) is a mycotoxin exhibiting nephrotoxic and potential carcinogenic activity. We investigated the cross‐talk between micro RNA s, nuclear factor E 2‐related factor 2 ( N rf2), and heme oxygenase‐1 ( HO ‐1) in ochratoxin A ‐mediated effects. Methods and results In porcine renal proximal tubular cells, OTA increased expression of profibrotic transforming growth factors β ( TGF β) while concomitantly decreasing expression of N rf2, HO ‐1, and erythropoietin. Adenoviral overexpression of N rf2 counteracted OTA ‐mediated reduction in HO ‐1 and erythropoietin expression and cell proliferation as well as increase in reactive oxygen species ( ROS ) generation and TGF β expression. Additionally, inhibition of HO activity enhanced whereas adenoviral overexpression of HO ‐1 reduced expression of TGF β. Moreover, antioxidants, N ‐acetyl‐cysteine and desferioxamine, prevented OTA ‐mediated enhancement of ROS generation, and TGF β expression. Finally, OTA modulated micro RNA processing by upregulating LIN eage protein 28 and D i G eorge syndrome critical region‐8, increasing the total pool of cellular micro RNA s and elevating the expression of mi R ‐132 and mi R ‐200c. Inhibition of mi R ‐132 by specific antagomir restored the OTA ‐driven reduction in N rf2 expression. Moreover, anti‐mi R ‐132 and anti‐mi R ‐200c counteracted OTA ‐mediated decrease in HO ‐1 levels as well as increase in ROS production and TGF β expression. Conclusion We showed that attenuation of N rf2 and HO ‐1 expression through induction of mi R ‐132 and mi R ‐200c by OTA elevates ROS levels and profibrotic TGF β expression." @default.
- W2073865764 created "2016-06-24" @default.
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- W2073865764 date "2012-12-28" @default.
- W2073865764 modified "2023-10-17" @default.
- W2073865764 title "Cross‐talk between micro<scp>RNA</scp>s, nuclear factor <scp>E</scp>2‐related factor 2, and heme oxygenase‐1 in ochratoxin <scp>A</scp>‐induced toxic effects in renal proximal tubular epithelial cells" @default.
- W2073865764 cites W1489063373 @default.
- W2073865764 cites W1515497590 @default.
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- W2073865764 cites W1978496143 @default.
- W2073865764 cites W1980913050 @default.
- W2073865764 cites W1988666366 @default.
- W2073865764 cites W1995910926 @default.
- W2073865764 cites W2005645711 @default.
- W2073865764 cites W2009180611 @default.
- W2073865764 cites W2009462641 @default.
- W2073865764 cites W2010839828 @default.
- W2073865764 cites W2012810666 @default.
- W2073865764 cites W2013852511 @default.
- W2073865764 cites W2014280885 @default.
- W2073865764 cites W2014729582 @default.
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- W2073865764 doi "https://doi.org/10.1002/mnfr.201200456" @default.
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