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- W2073878968 abstract "In a murine model of experimental Trypanosoma cruzi (H8 strain) infection, we investigated the induction of protective immunity against the domains [amino (A), repeats (R) and carboxyl (C)] of the surface protein (SP), a member of the trans-sialidase (TS) superfamily. Recombinant proteins and plasmid DNA coding for the respective proteins were used to immunize BALB/c mice, and the humoral response and cytokine levels were analysed. Immunization with the recombinant proteins induced higher levels of anti-TcSP antibodies than immunization with the corresponding DNAs, and analysis of serum cytokines showed that immunization with both recombinant proteins and naked DNA resulted in a Th1–Th2 mixed T-cell response. Mice immunized with either recombinant proteins or plasmid DNA were infected with blood trypomastigotes. The recombinant protein-immunized mice showed a variable reduction in peak parasitemia, and most died by day 60. Only the pBKTcSPR-immunized mice exhibited a significant reduction in peak parasitemia and survived the lethal challenge. DNA-based immunization with DNA coding for the repeats domain of TcSP is a good candidate for the development of a vaccine against experimental T. cruzi infection." @default.
- W2073878968 created "2016-06-24" @default.
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- W2073878968 date "2012-12-13" @default.
- W2073878968 modified "2023-10-18" @default.
- W2073878968 title "Differential immune response in mice immunized with the A, R or C domain from TcSP protein of<i>Trypanosoma cruzi</i>or with the coding DNAs" @default.
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- W2073878968 doi "https://doi.org/10.1111/pim.12017" @default.
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