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• W2073885497 abstract "Abstract Collapsin response mediator protein 4 ( CRMP 4) is a molecular marker for immature neurons but only limited information is available on the spatiotemporal gene expression changes of Crmp4 in the developing rodent. In the present study, the variation of CRMP 4 m RNA expression in the mouse brain was investigated from postnatal day ( PD ) 0 (the day of birth) to adulthood by in situ hybridization. The hybridization signals were broadly detected on PD 0 and regional changes in expression during development were noted. Expression patterns of CRMP 4 m RNA were classified into the following three types: (i) signals that were strongest on PD 0 or PD 7, weak or undetectable on PD 14, and absent in adulthood: this pattern was observed in most brain areas; (ii) signals that were first detected on PD 0 or PD 7 and persisted into adulthood: this pattern was seen in the dentate gyrus and subventricular zone of the olfactory bulb ( OB ); and (iii) signals that were strongest on PD 0 and decreased gradually with age but were still detectable in adulthood: this pattern was identified for the first time in the mitral cell layer of the OB . Analysis using quantitative real‐time RT ‐ PCR confirmed higher expression of CRMP 4 m RNA in the OB than in other adult brain regions. The persistence of CRMP 4 m RNA in the adult OB , including the mitral cell layer, suggests the possibility of both neurogenetic and non‐neurogenetic functional roles of CRMP 4 in this region." @default.
• W2073885497 created "2016-06-24" @default.
• W2073885497 creator A5000565194 @default.
• W2073885497 creator A5056551591 @default.
• W2073885497 date "2012-07-22" @default.
• W2073885497 modified "2023-10-05" @default.
• W2073885497 title "Postnatal alteration of collapsin response mediator protein 4 m<scp>RNA</scp> expression in the mouse brain" @default.
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• W2073885497 doi "https://doi.org/10.1111/j.1469-7580.2012.01544.x" @default.
• W2073885497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3458253" @default.
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