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- W2073886248 abstract "We investigated the locus of the charge immobilization in S4 voltage sensing segments of skeletal muscle sodium channels. To do this we compared the effects of charge reversing mutations of outer and central arginine or lysine residues using the cut open oocyte configuration. While reversal of charge at R1448 (R1 in DIV S4) produced a depolarizing effect on IV and QV curves, and limited immobilization of the gating charge, the analogous mutation at K1126 (K1 in DIII S4) had no effect. Reversal of charge at R4 and R5 in both DIII S4 and DIV S4 also limited immobilization of the gating charge. Dependence on charge for the effects of mutations at these loci was examined by substituting the native arginine residue with lysine. Charge substitution at R1 in DIV S4 and at R5 in DIII S4 or DIV S4 partially restored QV and gating charge immobilization parameters to the wild type phenotype, whereas charge substitution at R4 in either DIII S4 or DIV S4 did not. Effects of R1457E and R1457K (R4 in DIV S4) on gating charge remobilization suggested that this residue plays a pivotal role in gating charge movement associated with accessibility of the IFMT motif during fast inactivation. This work was supported by NIH R15NS064556-01 to JRG and NIH P20RR16454 to ISU from the INBRE program of the National Center for Research Resources." @default.
- W2073886248 created "2016-06-24" @default.
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- W2073886248 date "2010-01-01" @default.
- W2073886248 modified "2023-09-26" @default.
- W2073886248 title "Nav1.4 Voltage Sensor Residues Immobilized During Fast Inactivation" @default.
- W2073886248 doi "https://doi.org/10.1016/j.bpj.2009.12.4200" @default.
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