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• W2073892783 abstract "Exploitation of biological properties unique to cancer cells may provide a novel approach to overcome difficult challenges to the treatment of advanced melanoma. In order to develop melanoma-targeted chemothermoimmunotherapy, a melanogenesis substrate, N-propionyl-4-S-cysteaminylphenol (NPrCAP), sulfur-amine analogue of tyrosine, was conjugated with magnetite nanoparticles. NPrCAP was exploited from melanogenesis substrates, which are expected to be selectively incorporated into melanoma cells and produce highly reactive free radicals through reacting with tyrosinase, resulting in chemotherapeutic and immunotherapeutic effects by oxidative stress and apoptotic cell death. Magnetite nanoparticles were conjugated with NPrCAP to introduce thermotherapeutic and immunotherapeutic effects through nonapoptotic cell death and generation of heat shock protein (HSP) upon exposure to alternating magnetic field (AMF). During these therapeutic processes, NPrCAP was also expected to provide melanoma-targeted drug delivery system." @default.
• W2073892783 created "2016-06-24" @default.
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• W2073892783 date "2013-01-01" @default.
• W2073892783 modified "2023-10-16" @default.
• W2073892783 title "Melanoma-Targeted Chemothermotherapy and<i>In Situ</i>Peptide Immunotherapy through HSP Production by Using Melanogenesis Substrate, NPrCAP, and Magnetite Nanoparticles" @default.
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• W2073892783 doi "https://doi.org/10.1155/2013/742925" @default.
• W2073892783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3595688" @default.
• W2073892783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23533767" @default.
• W2073892783 hasPublicationYear "2013" @default.
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