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- W2073897828 abstract "The optically pure enantiomers of N'-norphenserine (15, 16) were synthesized and its racemate 17 was prepared by mixing equal parts of each enantiomer. (-)-N'-Norphenserine (15) was prepared by partial synthesis initiatedfrom the natural product, (-)-physostigmine (1). (+)-N'-Norphenserine (16) was prepared by total synthesis using the Julian oxindole route, with modifications. The in vitro inhibitory activities of 15-17 were quantified against human erythrocyte AChE and plasma BChE as well as against human neuroblastoma cell β-amyloid precursor protein secretion in cell culture. All were active. Racemic compound (17) with a high AChE and β-amyloid precursor protein inhibitory action may warrant further assessment in Alzheimer's disease models." @default.
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- W2073897828 date "2003-01-01" @default.
- W2073897828 modified "2023-09-23" @default.
- W2073897828 title "Racemic N1-Norphenserine and Its Enantiomers: Unpredicted Inhibition of Human Acetyl- and Butyrylcholinesterase and β-Amyloid Precursor Protein in vitro" @default.
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- W2073897828 doi "https://doi.org/10.3987/com-03-s15" @default.
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