Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073917960> ?p ?o ?g. }
- W2073917960 endingPage "99" @default.
- W2073917960 startingPage "89" @default.
- W2073917960 abstract "Aplastic anemia is a rare life-threatening bone marrow failure that is characterized by bicytopenia or pancytopenia in the peripheral blood and a hypoplastic or aplastic bone marrow. The patients are at risk of infection and hemorrhage due to neutropenia and thrombocytopenia and suffer from symptoms of anemia. The main treatment approaches are allogeneic stem cell transplantation and immunosuppression. Here, we review current standard immunosuppression and the attempts that have been made in the past two decades to improve results: review of recent developments also reveals that sometimes not only the advent of new drugs, good ideas and well-designed clinical trials decide the progress in the field but also marketing considerations of pharmaceutical companies. Aplastic anemia experts unfortunately had to face the situation that efficient drugs were withdrawn simply for marketing considerations. We will discuss the current options and challenges in first-line treatment and management of relapsing and refractory patients with an emphasis on adult patients. Some promising new approaches are currently under investigation in prospective, randomized trials." @default.
- W2073917960 created "2016-06-24" @default.
- W2073917960 creator A5035886609 @default.
- W2073917960 creator A5068469918 @default.
- W2073917960 creator A5068820436 @default.
- W2073917960 date "2015-01-02" @default.
- W2073917960 modified "2023-09-27" @default.
- W2073917960 title "Immunosuppressive therapy for transplant-ineligible aplastic anemia patients" @default.
- W2073917960 cites W105676805 @default.
- W2073917960 cites W1502200885 @default.
- W2073917960 cites W1528743278 @default.
- W2073917960 cites W1541757900 @default.
- W2073917960 cites W1557532207 @default.
- W2073917960 cites W1580780731 @default.
- W2073917960 cites W1663740507 @default.
- W2073917960 cites W1820573680 @default.
- W2073917960 cites W1923634318 @default.
- W2073917960 cites W1961025943 @default.
- W2073917960 cites W1965089841 @default.
- W2073917960 cites W1970972261 @default.
- W2073917960 cites W1971557056 @default.
- W2073917960 cites W1972068967 @default.
- W2073917960 cites W1973040183 @default.
- W2073917960 cites W1976494283 @default.
- W2073917960 cites W1976995655 @default.
- W2073917960 cites W1978366547 @default.
- W2073917960 cites W1979836922 @default.
- W2073917960 cites W1981471794 @default.
- W2073917960 cites W1990250462 @default.
- W2073917960 cites W1990941789 @default.
- W2073917960 cites W1991157297 @default.
- W2073917960 cites W1992786956 @default.
- W2073917960 cites W1996485069 @default.
- W2073917960 cites W2000929442 @default.
- W2073917960 cites W2001531010 @default.
- W2073917960 cites W2006385065 @default.
- W2073917960 cites W2006468333 @default.
- W2073917960 cites W2011059381 @default.
- W2073917960 cites W2011297283 @default.
- W2073917960 cites W2011572042 @default.
- W2073917960 cites W2014581521 @default.
- W2073917960 cites W2015180063 @default.
- W2073917960 cites W2016294085 @default.
- W2073917960 cites W2016759622 @default.
- W2073917960 cites W2018678214 @default.
- W2073917960 cites W2020864215 @default.
- W2073917960 cites W2023361697 @default.
- W2073917960 cites W2023670986 @default.
- W2073917960 cites W2025954849 @default.
- W2073917960 cites W2028208596 @default.
- W2073917960 cites W2029335286 @default.
- W2073917960 cites W2032667154 @default.
- W2073917960 cites W2034732127 @default.
- W2073917960 cites W2034898311 @default.
- W2073917960 cites W2036245297 @default.
- W2073917960 cites W2037236933 @default.
- W2073917960 cites W2037713259 @default.
- W2073917960 cites W2040496171 @default.
- W2073917960 cites W2047157188 @default.
- W2073917960 cites W2048182519 @default.
- W2073917960 cites W2050945312 @default.
- W2073917960 cites W2052285621 @default.
- W2073917960 cites W2056235669 @default.
- W2073917960 cites W2057941074 @default.
- W2073917960 cites W2058174372 @default.
- W2073917960 cites W2059084010 @default.
- W2073917960 cites W2063629560 @default.
- W2073917960 cites W2064535295 @default.
- W2073917960 cites W2066484486 @default.
- W2073917960 cites W2067596358 @default.
- W2073917960 cites W2069700451 @default.
- W2073917960 cites W2071159074 @default.
- W2073917960 cites W2072515174 @default.
- W2073917960 cites W2076811581 @default.
- W2073917960 cites W2082980816 @default.
- W2073917960 cites W2084937921 @default.
- W2073917960 cites W2084968573 @default.
- W2073917960 cites W2088933082 @default.
- W2073917960 cites W2089278876 @default.
- W2073917960 cites W2091483057 @default.
- W2073917960 cites W2091525085 @default.
- W2073917960 cites W2094277327 @default.
- W2073917960 cites W2095276384 @default.
- W2073917960 cites W2103242373 @default.
- W2073917960 cites W2106339572 @default.
- W2073917960 cites W2107643897 @default.
- W2073917960 cites W2127596128 @default.
- W2073917960 cites W2127660435 @default.
- W2073917960 cites W2131799119 @default.
- W2073917960 cites W2133676382 @default.
- W2073917960 cites W2135634159 @default.
- W2073917960 cites W2138356732 @default.
- W2073917960 cites W2142353478 @default.
- W2073917960 cites W2149753414 @default.
- W2073917960 cites W2150498923 @default.
- W2073917960 cites W2153556905 @default.
- W2073917960 cites W2170313511 @default.
- W2073917960 cites W2171955226 @default.