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• W2073923257 startingPage "335" @default.
• W2073923257 abstract "Studies of sensory pathways in several species indicate that the extent and form of reorganization resulting from deafferentation early in life vs. adulthood are not the same. The reasons for such differences are not well understood. To gain further insight into age-dependent mechanisms of reorganization, this study compared the consequences of neonatal vs. adult forelimb amputation in rats at multiple levels of the sensory pathway, including primary somatosensory cortex, brainstem, and dorsal root ganglia. At the cortical level, the average area of the functional forelimb-stump representation from rats amputated as adults was significantly smaller (P < 0.05) than that of neonatally amputated rats (4.3 +/- 1.3 mm(2) vs. 6.6 +/- 1.5 mm(2), respectively). At the brainstem level, neonatally amputated rat cuneate neurons possessed the following responsivities: 20% stump responsive, 40% responsive to both stump and hindlimb, 30% responsive to another body region, and 10% unresponsive. In contrast, cuneate neurons of adult amputated rats were 70% stump responsive, 2% responsive to both stump and hindlimb, and 30% unresponsive. A significantly (P < 0.001) greater percentage of the C(6)-C(8) dorsal root ganglia neurons of adult amputated rats were unresponsive to peripheral stimulation vs. neurons from neonatally amputated rats (48% vs. 16%, respectively). These results indicate that the reorganization that occurs in response to forelimb amputation at birth vs. adulthood is distinctly different at each of these levels of the dorsal column-medial lemniscal pathway. Possible mechanisms to account for these differences are considered." @default.
• W2073923257 created "2016-06-24" @default.
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• W2073923257 date "2003-09-03" @default.
• W2073923257 modified "2023-09-23" @default.
• W2073923257 title "Comparison of reorganization of the somatosensory system in rats that sustained forelimb removal as neonates and as adults" @default.
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• W2073923257 doi "https://doi.org/10.1002/cne.10849" @default.
• W2073923257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12966559" @default.
• W2073923257 hasPublicationYear "2003" @default.
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