Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073938963> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2073938963 abstract "We report the design and synthesis of a new class of piperazine-pyridazinone analogues. The arylpiperazine moiety, the length of the spacer, and the terminal molecular fragment were varied to evaluate their influence in determining the affinity of the new compounds toward the alpha1-adrenergic receptor (alpha1-AR), alpha2-adrenergic receptor (alpha2-AR), and the 5-HT1A serotoninergic receptor (5-HT1AR). Biological data showed that most of the compounds have an alpha1-AR affinity in the nanomolar or subnanomolar range, while affinity toward the other two receptors was lower in most cases. However, several of the tested compounds also showed very good (in the nanomolar range) or moderate affinity toward the 5-HT1AR subtype." @default.
- W2073938963 created "2016-06-24" @default.
- W2073938963 creator A5003473752 @default.
- W2073938963 creator A5004493180 @default.
- W2073938963 creator A5008783082 @default.
- W2073938963 creator A5032250855 @default.
- W2073938963 creator A5052430017 @default.
- W2073938963 creator A5087172463 @default.
- W2073938963 date "2006-04-01" @default.
- W2073938963 modified "2023-09-23" @default.
- W2073938963 title "Synthesis of new piperazine–pyridazinone derivatives and their binding affinity toward α1-, α2-adrenergic and 5-HT1A serotoninergic receptors" @default.
- W2073938963 cites W1775749144 @default.
- W2073938963 cites W1965006436 @default.
- W2073938963 cites W1970239019 @default.
- W2073938963 cites W1989787126 @default.
- W2073938963 cites W2003935594 @default.
- W2073938963 cites W2004507156 @default.
- W2073938963 cites W2032646877 @default.
- W2073938963 cites W2039169654 @default.
- W2073938963 cites W2049000252 @default.
- W2073938963 cites W2050596412 @default.
- W2073938963 cites W2073132416 @default.
- W2073938963 cites W2074631079 @default.
- W2073938963 cites W2091352788 @default.
- W2073938963 cites W2123109304 @default.
- W2073938963 cites W2175282196 @default.
- W2073938963 cites W2951043546 @default.
- W2073938963 doi "https://doi.org/10.1016/j.bmc.2005.12.009" @default.
- W2073938963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16376083" @default.
- W2073938963 hasPublicationYear "2006" @default.
- W2073938963 type Work @default.
- W2073938963 sameAs 2073938963 @default.
- W2073938963 citedByCount "38" @default.
- W2073938963 countsByYear W20739389632012 @default.
- W2073938963 countsByYear W20739389632013 @default.
- W2073938963 countsByYear W20739389632014 @default.
- W2073938963 countsByYear W20739389632015 @default.
- W2073938963 countsByYear W20739389632016 @default.
- W2073938963 countsByYear W20739389632018 @default.
- W2073938963 countsByYear W20739389632020 @default.
- W2073938963 countsByYear W20739389632021 @default.
- W2073938963 countsByYear W20739389632023 @default.
- W2073938963 crossrefType "journal-article" @default.
- W2073938963 hasAuthorship W2073938963A5003473752 @default.
- W2073938963 hasAuthorship W2073938963A5004493180 @default.
- W2073938963 hasAuthorship W2073938963A5008783082 @default.
- W2073938963 hasAuthorship W2073938963A5032250855 @default.
- W2073938963 hasAuthorship W2073938963A5052430017 @default.
- W2073938963 hasAuthorship W2073938963A5087172463 @default.
- W2073938963 hasConcept C170493617 @default.
- W2073938963 hasConcept C178790620 @default.
- W2073938963 hasConcept C185592680 @default.
- W2073938963 hasConcept C2775864247 @default.
- W2073938963 hasConcept C2776201271 @default.
- W2073938963 hasConcept C2776568683 @default.
- W2073938963 hasConcept C37000724 @default.
- W2073938963 hasConcept C40465926 @default.
- W2073938963 hasConcept C55493867 @default.
- W2073938963 hasConcept C71240020 @default.
- W2073938963 hasConceptScore W2073938963C170493617 @default.
- W2073938963 hasConceptScore W2073938963C178790620 @default.
- W2073938963 hasConceptScore W2073938963C185592680 @default.
- W2073938963 hasConceptScore W2073938963C2775864247 @default.
- W2073938963 hasConceptScore W2073938963C2776201271 @default.
- W2073938963 hasConceptScore W2073938963C2776568683 @default.
- W2073938963 hasConceptScore W2073938963C37000724 @default.
- W2073938963 hasConceptScore W2073938963C40465926 @default.
- W2073938963 hasConceptScore W2073938963C55493867 @default.
- W2073938963 hasConceptScore W2073938963C71240020 @default.
- W2073938963 hasLocation W20739389631 @default.
- W2073938963 hasLocation W20739389632 @default.
- W2073938963 hasOpenAccess W2073938963 @default.
- W2073938963 hasPrimaryLocation W20739389631 @default.
- W2073938963 hasRelatedWork W1981619513 @default.
- W2073938963 hasRelatedWork W1993238698 @default.
- W2073938963 hasRelatedWork W2036812642 @default.
- W2073938963 hasRelatedWork W2053127867 @default.
- W2073938963 hasRelatedWork W2071884076 @default.
- W2073938963 hasRelatedWork W2079846365 @default.
- W2073938963 hasRelatedWork W2088874841 @default.
- W2073938963 hasRelatedWork W2115182798 @default.
- W2073938963 hasRelatedWork W2156364714 @default.
- W2073938963 hasRelatedWork W2405415916 @default.
- W2073938963 isParatext "false" @default.
- W2073938963 isRetracted "false" @default.
- W2073938963 magId "2073938963" @default.
- W2073938963 workType "article" @default.