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- W2073952613 abstract "The constitutively active Gqalpha mutant construct (GqalphaQ-L) in Xenopus early embryos was overexpressed and the effects on dorsoventral patterning examined. It was found that prolonged stimulation of inositol 1,4,5-trisphosphate (IP3)-Ca2+ signaling by overexpression of GqalphaQ-L led to desensitization of IP3-induced Ca2+ release (IICR). Desensitization of IICR on the ventral side specifically induced an ectopic dorsal axis due to the conversion of ventral marginal mesoderm to adopt a dorsal fate. This effect of desensitization resembles that of inhibitory antibodies against the IP3 receptor, as reported previously. These results strengthen the earlier finding that active IP3-Ca2+ signaling functions in ventral signaling during the early embryonic development of Xenopus. Furthermore, the nature of downregulation of the Xenopus IP3 receptor through continuous stimulation of IP3-Ca2+ signaling might play a role in regulating endogenous IP3-Ca2+ signaling in Xenopus early development." @default.
- W2073952613 created "2016-06-24" @default.
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- W2073952613 date "2000-08-19" @default.
- W2073952613 modified "2023-10-17" @default.
- W2073952613 title "Desensitization of IP3-induced Ca2+ release by overexpression of a constitutively active Gqalpha protein converts ventral to dorsal fate in Xenopus early embryos" @default.
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- W2073952613 doi "https://doi.org/10.1046/j.1440-169x.2000.00519.x" @default.
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