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- W2073955470 abstract "The dynamical translocation of lipids from one leaflet to another due to membrane permeabilization driven by nanosecond, high-intensity (>100kV/cm) electrical pulses has been probed. Our simulations show that lipid molecules can translocate by diffusion through water-filled nanopores which form following high voltage application. Our focus is on multiple pulsing, and such simulations are relevant to gauge the time duration over which nanopores might remain open, and facilitate continued lipid translocations and membrane transport. Our results are indicative of a N(½) scaling with pulse number for the pore radius. These results bode well for the use of pulse trains in biomedical applications, not only due to cumulative behaviors and in reducing electric intensities and pulsing hardware, but also due to the possibility of long-lived thermo-electric physics near the membrane, and the possibility for pore coalescence." @default.
- W2073955470 created "2016-06-24" @default.
- W2073955470 creator A5009157184 @default.
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- W2073955470 date "2014-03-01" @default.
- W2073955470 modified "2023-09-25" @default.
- W2073955470 title "Numerical study of lipid translocation driven by nanoporation due to multiple high-intensity, ultrashort electrical pulses" @default.
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- W2073955470 doi "https://doi.org/10.1016/j.bbamem.2013.11.003" @default.
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