FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073960226> ?p ?o ?g. }

• W2073960226 endingPage "190" @default.
• W2073960226 startingPage "183" @default.
• W2073960226 abstract "Proteoglycan-4 (Prg4) protects synovial joints from arthropathic changes by mechanisms that are incompletely understood. Parathyroid hormone (PTH), known for its anabolic actions in bone, increases Prg4 expression and has been reported to inhibit articular cartilage degeneration in arthropathic joints. To investigate the effect of Prg4 and PTH on articular cartilage, 16-week-old Prg4 mutant and wild-type mice were treated with intermittent PTH (1–34) or vehicle control daily for six weeks. Analyses included histology of the knee joint, micro-CT of the distal femur, and serum biochemical analysis of type II collagen fragments (CTX-II). Compared to wild-type littermates, Prg4 mutant mice had an acellular layer of material lining the surfaces of the articular cartilage and menisci, increased articular cartilage degradation, increased serum CTX-II concentrations, decreased articular chondrocyte apoptosis, increased synovium SDF-1 expression, and irregularly contoured subchondral bone. PTH-treated Prg4 mutant mice developed a secondary deposit overlaying the acellular layer of material lining the joint surfaces, but PTH-treatment did not alter signs of articular cartilage degeneration in Prg4 mutant mice. The increased joint SDF-1 levels and irregular subchondral bone found in Prg4 mutant mice introduce novel candidate mechanisms by which Prg4 protects articular cartilage. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 183–190, 2013" @default.
• W2073960226 created "2016-06-24" @default.
• W2073960226 creator A5010672369 @default.
• W2073960226 creator A5017391926 @default.
• W2073960226 creator A5035424698 @default.
• W2073960226 creator A5036708496 @default.
• W2073960226 creator A5043128714 @default.
• W2073960226 creator A5049156516 @default.
• W2073960226 creator A5059584056 @default.
• W2073960226 creator A5066323693 @default.
• W2073960226 creator A5068195664 @default.
• W2073960226 creator A5074901217 @default.
• W2073960226 creator A5080856310 @default.
• W2073960226 date "2012-08-15" @default.
• W2073960226 modified "2023-10-16" @default.
• W2073960226 title "Impact of proteoglycan-4 and parathyroid hormone on articular cartilage" @default.
• W2073960226 cites W1532082365 @default.
• W2073960226 cites W1598097915 @default.
• W2073960226 cites W1976774264 @default.
• W2073960226 cites W1976996315 @default.
• W2073960226 cites W1982171868 @default.
• W2073960226 cites W1990591381 @default.
• W2073960226 cites W2015769931 @default.
• W2073960226 cites W2021862667 @default.
• W2073960226 cites W2029122211 @default.
• W2073960226 cites W2029958443 @default.
• W2073960226 cites W2038932665 @default.
• W2073960226 cites W2045147196 @default.
• W2073960226 cites W2045503800 @default.
• W2073960226 cites W2049220563 @default.
• W2073960226 cites W2059996143 @default.
• W2073960226 cites W2061860330 @default.
• W2073960226 cites W2092926936 @default.
• W2073960226 cites W2099427592 @default.
• W2073960226 cites W2100099085 @default.
• W2073960226 cites W2109598982 @default.
• W2073960226 cites W2126202517 @default.
• W2073960226 cites W2141837666 @default.
• W2073960226 cites W2475997760 @default.
• W2073960226 cites W4254025084 @default.
• W2073960226 doi "https://doi.org/10.1002/jor.22207" @default.
• W2073960226 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3502647" @default.
• W2073960226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22898906" @default.
• W2073960226 hasPublicationYear "2012" @default.
• W2073960226 type Work @default.
• W2073960226 sameAs 2073960226 @default.
• W2073960226 citedByCount "7" @default.
• W2073960226 countsByYear W20739602262014 @default.
• W2073960226 countsByYear W20739602262015 @default.
• W2073960226 countsByYear W20739602262016 @default.
• W2073960226 countsByYear W20739602262019 @default.
• W2073960226 countsByYear W20739602262020 @default.
• W2073960226 countsByYear W20739602262022 @default.
• W2073960226 crossrefType "journal-article" @default.
• W2073960226 hasAuthorship W2073960226A5010672369 @default.
• W2073960226 hasAuthorship W2073960226A5017391926 @default.
• W2073960226 hasAuthorship W2073960226A5035424698 @default.
• W2073960226 hasAuthorship W2073960226A5036708496 @default.
• W2073960226 hasAuthorship W2073960226A5043128714 @default.
• W2073960226 hasAuthorship W2073960226A5049156516 @default.
• W2073960226 hasAuthorship W2073960226A5059584056 @default.
• W2073960226 hasAuthorship W2073960226A5066323693 @default.
• W2073960226 hasAuthorship W2073960226A5068195664 @default.
• W2073960226 hasAuthorship W2073960226A5074901217 @default.
• W2073960226 hasAuthorship W2073960226A5080856310 @default.
• W2073960226 hasBestOaLocation W20739602261 @default.
• W2073960226 hasConcept C105702510 @default.
• W2073960226 hasConcept C126322002 @default.
• W2073960226 hasConcept C134018914 @default.
• W2073960226 hasConcept C142724271 @default.
• W2073960226 hasConcept C185592680 @default.
• W2073960226 hasConcept C197534660 @default.
• W2073960226 hasConcept C204787440 @default.
• W2073960226 hasConcept C2776164576 @default.
• W2073960226 hasConcept C2780550940 @default.
• W2073960226 hasConcept C2781013607 @default.
• W2073960226 hasConcept C2781208988 @default.
• W2073960226 hasConcept C2781403057 @default.
• W2073960226 hasConcept C3020332539 @default.
• W2073960226 hasConcept C519063684 @default.
• W2073960226 hasConcept C71924100 @default.
• W2073960226 hasConceptScore W2073960226C105702510 @default.
• W2073960226 hasConceptScore W2073960226C126322002 @default.
• W2073960226 hasConceptScore W2073960226C134018914 @default.
• W2073960226 hasConceptScore W2073960226C142724271 @default.
• W2073960226 hasConceptScore W2073960226C185592680 @default.
• W2073960226 hasConceptScore W2073960226C197534660 @default.
• W2073960226 hasConceptScore W2073960226C204787440 @default.
• W2073960226 hasConceptScore W2073960226C2776164576 @default.
• W2073960226 hasConceptScore W2073960226C2780550940 @default.
• W2073960226 hasConceptScore W2073960226C2781013607 @default.
• W2073960226 hasConceptScore W2073960226C2781208988 @default.
• W2073960226 hasConceptScore W2073960226C2781403057 @default.
• W2073960226 hasConceptScore W2073960226C3020332539 @default.
• W2073960226 hasConceptScore W2073960226C519063684 @default.
• W2073960226 hasConceptScore W2073960226C71924100 @default.
• W2073960226 hasIssue "2" @default.
• W2073960226 hasLocation W20739602261 @default.

• next