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- W2073962508 abstract "The enantiomers of the dopamine (DA) agonist PD 128483 (1) have been synthesized and characterized biochemically (D1, D2 receptor binding, effects on rat brain DA synthesis), electrophysiologically (inhibition of DA neuron firing) and behaviorally (effects on rat exploratory locomotor activity). While R-(+)−1 is a potent D2 agonist that stimulates both pre- and postsynaptic DA receptors, S-(−)−1 is a weak partial DA agonist able to stimulate only the more sensitive presynaptic DA receptors (DA autoreceptors)." @default.
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- W2073962508 date "1991-01-01" @default.
- W2073962508 modified "2023-09-30" @default.
- W2073962508 title "Synthesis and dopaminergic activity of the enantiomers of 6-methyl-4,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine (PD 128483)." @default.
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- W2073962508 doi "https://doi.org/10.1016/s0960-894x(01)80462-5" @default.
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