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- W2073963206 abstract "Abstract Thirty patients with Paget's disease were treated with a combination of EHDP and calcitonin. EHDP was given orally (7.5 mg/kg body weight/day) and calcitonin, either as synthetic human calcitonin 0.5 mg or as salmon calcitonin 50 or 100 MRC units day, by self-administered subcutaneous injection. All patients noted subjective improvement, being able to walk further or work longer before pain developed. Twenty five obtained complete biochemical remission in six to twelve months, while five obtained near to normal values for alkaline phosphatase and hydroxyproline. Iliac crest biopsies showed a decrease in the volume percentage of osteoid and in numbers of asteoclasts, and bone scans improved. At six months calcium balances had become more positive, consistent with continued mineralization of earlier formed bone. Seven patients suffered recurrence within three months of withdrawal of therapy. Maintained remission has been observed in six patients followed for more than half a year, in six followed for more than a year and in six followed for more than two years." @default.
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- W2073963206 date "1978-01-01" @default.
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- W2073963206 title "Treatment of Paget's disease with combined calcitonin and diphosphonate (EHDP)" @default.
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- W2073963206 doi "https://doi.org/10.1016/0221-8747(78)90010-3" @default.
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