FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073968081> ?p ?o ?g. }

• W2073968081 endingPage "316" @default.
• W2073968081 startingPage "312" @default.
• W2073968081 abstract "Uptake of neurotransmitters into synaptic vesicles occurs through specific transport proteins which are driven by an ATPase-generated electrochemical force consisting of a proton gradient and a membrane potential. In this study we examined the effects of bilirubin, a well known neurotoxic agent, on the vesicle uptake both of [3H]dopamine (which is driven mostly by the proton gradient) and [3H]glutamate (which is driven mostly by the membrane potential), and compared these to the vesicular proton gradient, which was estimated by analyzing the uptake of [14C]methylamine. Bilirubin inhibited the uptake of both dopamine and glutamate (p < 0.01), with an identical dose-response curve for both transmitters. Inhibition was detected readily at 75 microM. The effects of bilirubin were dependent on the concentration of vesicles in the assay, suggesting that the concentration of bilirubin in the membranes and not the water phase was important. Bilirubin also decreased uptake-dependent efflux of dopamine from the vesicles. In contrast, bilirubin had no effect on the vesicular proton gradient, as measured by methylamine uptake. Our results show that bilirubin has essentially identical inhibitory effects on the uptake of both a monoamine transmitter and an amino acid transmitter into synaptic vesicles, but does not influence the vesicular H+-ATPase or proton translocation. Our data suggest an inhibitory interaction between bilirubin and several transport proteins in synaptic vesicle membranes." @default.
• W2073968081 created "2016-06-24" @default.
• W2073968081 creator A5001562001 @default.
• W2073968081 creator A5010774921 @default.
• W2073968081 creator A5040751788 @default.
• W2073968081 creator A5075274115 @default.
• W2073968081 date "1998-09-01" @default.
• W2073968081 modified "2023-09-26" @default.
• W2073968081 title "Bilirubin Inhibits Transport of Neurotransmitters in Synaptic Vesicles" @default.
• W2073968081 cites W1494188991 @default.
• W2073968081 cites W1515670497 @default.
• W2073968081 cites W1532965526 @default.
• W2073968081 cites W1775749144 @default.
• W2073968081 cites W1937429153 @default.
• W2073968081 cites W1973567298 @default.
• W2073968081 cites W1984142824 @default.
• W2073968081 cites W1999434743 @default.
• W2073968081 cites W2004754982 @default.
• W2073968081 cites W2018960634 @default.
• W2073968081 cites W2025407224 @default.
• W2073968081 cites W2026235545 @default.
• W2073968081 cites W2035501441 @default.
• W2073968081 cites W2043386392 @default.
• W2073968081 cites W2054259802 @default.
• W2073968081 cites W2058456173 @default.
• W2073968081 cites W2059554761 @default.
• W2073968081 cites W2070556319 @default.
• W2073968081 cites W2079905807 @default.
• W2073968081 cites W2085611363 @default.
• W2073968081 cites W2091195998 @default.
• W2073968081 cites W2135858785 @default.
• W2073968081 cites W2153821937 @default.
• W2073968081 cites W2196380229 @default.
• W2073968081 doi "https://doi.org/10.1203/00006450-199809000-00008" @default.
• W2073968081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9727706" @default.
• W2073968081 hasPublicationYear "1998" @default.
• W2073968081 type Work @default.
• W2073968081 sameAs 2073968081 @default.
• W2073968081 citedByCount "38" @default.
• W2073968081 countsByYear W20739680812012 @default.
• W2073968081 countsByYear W20739680812013 @default.
• W2073968081 countsByYear W20739680812014 @default.
• W2073968081 countsByYear W20739680812017 @default.
• W2073968081 countsByYear W20739680812018 @default.
• W2073968081 countsByYear W20739680812019 @default.
• W2073968081 countsByYear W20739680812020 @default.
• W2073968081 countsByYear W20739680812022 @default.
• W2073968081 countsByYear W20739680812023 @default.
• W2073968081 crossrefType "journal-article" @default.
• W2073968081 hasAuthorship W2073968081A5001562001 @default.
• W2073968081 hasAuthorship W2073968081A5010774921 @default.
• W2073968081 hasAuthorship W2073968081A5040751788 @default.
• W2073968081 hasAuthorship W2073968081A5075274115 @default.
• W2073968081 hasBestOaLocation W20739680811 @default.
• W2073968081 hasConcept C12554922 @default.
• W2073968081 hasConcept C130316041 @default.
• W2073968081 hasConcept C134018914 @default.
• W2073968081 hasConcept C148785051 @default.
• W2073968081 hasConcept C170493617 @default.
• W2073968081 hasConcept C185592680 @default.
• W2073968081 hasConcept C187714386 @default.
• W2073968081 hasConcept C2775864247 @default.
• W2073968081 hasConcept C2776219046 @default.
• W2073968081 hasConcept C2777513400 @default.
• W2073968081 hasConcept C2778969155 @default.
• W2073968081 hasConcept C41625074 @default.
• W2073968081 hasConcept C513476851 @default.
• W2073968081 hasConcept C55493867 @default.
• W2073968081 hasConcept C61174792 @default.
• W2073968081 hasConcept C86803240 @default.
• W2073968081 hasConcept C90424259 @default.
• W2073968081 hasConceptScore W2073968081C12554922 @default.
• W2073968081 hasConceptScore W2073968081C130316041 @default.
• W2073968081 hasConceptScore W2073968081C134018914 @default.
• W2073968081 hasConceptScore W2073968081C148785051 @default.
• W2073968081 hasConceptScore W2073968081C170493617 @default.
• W2073968081 hasConceptScore W2073968081C185592680 @default.
• W2073968081 hasConceptScore W2073968081C187714386 @default.
• W2073968081 hasConceptScore W2073968081C2775864247 @default.
• W2073968081 hasConceptScore W2073968081C2776219046 @default.
• W2073968081 hasConceptScore W2073968081C2777513400 @default.
• W2073968081 hasConceptScore W2073968081C2778969155 @default.
• W2073968081 hasConceptScore W2073968081C41625074 @default.
• W2073968081 hasConceptScore W2073968081C513476851 @default.
• W2073968081 hasConceptScore W2073968081C55493867 @default.
• W2073968081 hasConceptScore W2073968081C61174792 @default.
• W2073968081 hasConceptScore W2073968081C86803240 @default.
• W2073968081 hasConceptScore W2073968081C90424259 @default.
• W2073968081 hasIssue "3" @default.
• W2073968081 hasLocation W20739680811 @default.
• W2073968081 hasLocation W20739680812 @default.
• W2073968081 hasOpenAccess W2073968081 @default.
• W2073968081 hasPrimaryLocation W20739680811 @default.
• W2073968081 hasRelatedWork W1983372821 @default.
• W2073968081 hasRelatedWork W1995323809 @default.
• W2073968081 hasRelatedWork W1998668957 @default.
• W2073968081 hasRelatedWork W2019922908 @default.
• W2073968081 hasRelatedWork W2042572088 @default.

• next