FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073970175> ?p ?o ?g. }

• W2073970175 abstract "Increased understanding of the molecular pathophysiology of metastatic renal cell carcinoma (mRCC) has led to development of antiangiogenic therapies in the past 5 years that significantly improved the prognosis. Vascular endothelial growth factor (VEGF) is a major growth factor in tumor angiogenesis and is implicated in tumor progression of several types of cancer, including mRCC. Use of 2 distinct approaches resulted in clinical efficacy in blocking the VEGF pathway: small molecule tyrosine kinase inhibitors (sunitinib, sorafenib, axitinib, pazopanib) and the humanized anti-VEGF monoclonal antibody bevacizumab that binds circulating VEGF and prevents activation of the VEGF receptor. In the 2 large phase III trials AVOREN and CALGB 90206, bevacizumab combined with interferon alfa demonstrated its efficacy as a first-line therapy in terms of progression-free survival. Nevertheless, in the era of targeted therapies, other studies are still needed to better obtain the maximal clinical benefit of bevacizumab. The aim of this overview is to report the current role of bevacizumab in the treatment of metastatic kidney cancer and to highlight possible combinations or sequential strategies that involve other targeted agents." @default.
• W2073970175 created "2016-06-24" @default.
• W2073970175 creator A5001628805 @default.
• W2073970175 creator A5013942703 @default.
• W2073970175 creator A5019624513 @default.
• W2073970175 creator A5037359039 @default.
• W2073970175 creator A5051297483 @default.
• W2073970175 creator A5073158835 @default.
• W2073970175 creator A5090082356 @default.
• W2073970175 date "2012-09-01" @default.
• W2073970175 modified "2023-10-18" @default.
• W2073970175 title "Reappraisal of the Role of Bevacizumab in the Therapeutic Strategy in Advanced Renal Cell Carcinoma" @default.
• W2073970175 cites W1487380784 @default.
• W2073970175 cites W1520255941 @default.
• W2073970175 cites W1545207088 @default.
• W2073970175 cites W1795082754 @default.
• W2073970175 cites W1886850372 @default.
• W2073970175 cites W1967154897 @default.
• W2073970175 cites W1983270148 @default.
• W2073970175 cites W2009334783 @default.
• W2073970175 cites W2023952988 @default.
• W2073970175 cites W2024586523 @default.
• W2073970175 cites W2046507292 @default.
• W2073970175 cites W2049792735 @default.
• W2073970175 cites W2086619383 @default.
• W2073970175 cites W2096704713 @default.
• W2073970175 cites W2099088585 @default.
• W2073970175 cites W2100669312 @default.
• W2073970175 cites W2104540972 @default.
• W2073970175 cites W2115005218 @default.
• W2073970175 cites W2119404465 @default.
• W2073970175 cites W2129820508 @default.
• W2073970175 cites W2138129102 @default.
• W2073970175 cites W2143782771 @default.
• W2073970175 cites W2143813821 @default.
• W2073970175 cites W2145224595 @default.
• W2073970175 cites W2146711059 @default.
• W2073970175 cites W2150725676 @default.
• W2073970175 cites W2153867442 @default.
• W2073970175 cites W2155012968 @default.
• W2073970175 cites W2157262448 @default.
• W2073970175 cites W2158734599 @default.
• W2073970175 cites W2160476851 @default.
• W2073970175 cites W2162424705 @default.
• W2073970175 cites W2166788033 @default.
• W2073970175 cites W2170089147 @default.
• W2073970175 cites W2341732647 @default.
• W2073970175 cites W2766384742 @default.
• W2073970175 cites W2768600953 @default.
• W2073970175 doi "https://doi.org/10.1016/j.clgc.2012.05.002" @default.
• W2073970175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22796529" @default.
• W2073970175 hasPublicationYear "2012" @default.
• W2073970175 type Work @default.
• W2073970175 sameAs 2073970175 @default.
• W2073970175 citedByCount "2" @default.
• W2073970175 countsByYear W20739701752013 @default.
• W2073970175 countsByYear W20739701752017 @default.
• W2073970175 crossrefType "journal-article" @default.
• W2073970175 hasAuthorship W2073970175A5001628805 @default.
• W2073970175 hasAuthorship W2073970175A5013942703 @default.
• W2073970175 hasAuthorship W2073970175A5019624513 @default.
• W2073970175 hasAuthorship W2073970175A5037359039 @default.
• W2073970175 hasAuthorship W2073970175A5051297483 @default.
• W2073970175 hasAuthorship W2073970175A5073158835 @default.
• W2073970175 hasAuthorship W2073970175A5090082356 @default.
• W2073970175 hasConcept C121608353 @default.
• W2073970175 hasConcept C126322002 @default.
• W2073970175 hasConcept C143998085 @default.
• W2073970175 hasConcept C167734588 @default.
• W2073970175 hasConcept C2776539811 @default.
• W2073970175 hasConcept C2776694085 @default.
• W2073970175 hasConcept C2777025900 @default.
• W2073970175 hasConcept C2777472916 @default.
• W2073970175 hasConcept C2777802072 @default.
• W2073970175 hasConcept C2778019345 @default.
• W2073970175 hasConcept C2778439243 @default.
• W2073970175 hasConcept C2778695046 @default.
• W2073970175 hasConcept C2779490328 @default.
• W2073970175 hasConcept C2780394083 @default.
• W2073970175 hasConcept C2781068499 @default.
• W2073970175 hasConcept C2781230642 @default.
• W2073970175 hasConcept C502942594 @default.
• W2073970175 hasConcept C71924100 @default.
• W2073970175 hasConceptScore W2073970175C121608353 @default.
• W2073970175 hasConceptScore W2073970175C126322002 @default.
• W2073970175 hasConceptScore W2073970175C143998085 @default.
• W2073970175 hasConceptScore W2073970175C167734588 @default.
• W2073970175 hasConceptScore W2073970175C2776539811 @default.
• W2073970175 hasConceptScore W2073970175C2776694085 @default.
• W2073970175 hasConceptScore W2073970175C2777025900 @default.
• W2073970175 hasConceptScore W2073970175C2777472916 @default.
• W2073970175 hasConceptScore W2073970175C2777802072 @default.
• W2073970175 hasConceptScore W2073970175C2778019345 @default.
• W2073970175 hasConceptScore W2073970175C2778439243 @default.
• W2073970175 hasConceptScore W2073970175C2778695046 @default.
• W2073970175 hasConceptScore W2073970175C2779490328 @default.
• W2073970175 hasConceptScore W2073970175C2780394083 @default.
• W2073970175 hasConceptScore W2073970175C2781068499 @default.
• W2073970175 hasConceptScore W2073970175C2781230642 @default.
• W2073970175 hasConceptScore W2073970175C502942594 @default.

• next