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• W2073970227 abstract "Gramicidin S, a cationic cyclic decapeptide, exhibits the potent antibiotic activity through perturbation of lipid bilayers of the bacterial membrane. From the screening of natural antibiotics, we identified gramicidin S as a potent inhibitor for cytochrome bd-type quinol oxidase from Escherichia coli. We found that gramicidin S inhibited the oxidase with IC50 of 3.5 μM by decreasing V max and the affinity for substrates but showed the stimulatory effect at low concentrations. Our findings would provide a new insight into the development of gramicidin S analogs, which do not share the target and mechanism with conventional antibiotics." @default.
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• W2073970227 date "2008-06-02" @default.
• W2073970227 modified "2023-10-18" @default.
• W2073970227 title "Gramicidin S identified as a potent inhibitor for cytochrome <i>bd</i> -type quinol oxidase" @default.
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• W2073970227 doi "https://doi.org/10.1016/j.febslet.2008.05.031" @default.
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