FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073970536> ?p ?o ?g. }

• W2073970536 endingPage "262" @default.
• W2073970536 startingPage "257" @default.
• W2073970536 abstract "The development of the central nervous system is influenced by sex steroids and by their metabolites. However, little information on the possible effects of steroid hormones on neuroblastoma cells is available. Human neuroblastoma cell lines have been used as a model of human neuroblasts in vitro to study the metabolism of steroid hormones; in addition, the effects of steroids and steroid antagonists on neuroblastoma cell growth have also been investigated. The results obtained show that SH-SY5Y human neuroblastoma cells may actively metabolize testosterone and progesterone to their respective 5 alpha-reduced metabolites and that differentiation of neuroblastoma cells is paralleled by a significant increase in expression of the type-1 5 alpha-reductase and of the formation of steroid metabolites. All these data are suggestive of a potential role of steroid 5 alpha-reduced metabolites in the biology of neuroblastoma cells. Studies performed to analyze the role of steroid hormones on neuroblastoma cell proliferation show that progesterone at low doses may induce minor stimulation, and at higher doses, a toxic effect on the neuroblastoma cell line SK-N-SH is seen. Moreover, the antiprogestin 17 beta-hydroxy-11 beta-(4-dimethylamino-phenyl-1)-17-(prop-1-ynyl)estra-4,9-dien+ ++-3-one (RU486) decreases the proliferation of these cells in a dose-dependent manner. The effect of RU486 is not antagonized by either progesterone or dexamethasone, a result that seems to exclude the action of RU486 via classic intracellular steroid hormone receptors." @default.
• W2073970536 created "2016-06-24" @default.
• W2073970536 creator A5000101718 @default.
• W2073970536 creator A5005948227 @default.
• W2073970536 creator A5009283840 @default.
• W2073970536 creator A5027154404 @default.
• W2073970536 creator A5044387326 @default.
• W2073970536 creator A5059962048 @default.
• W2073970536 creator A5088952771 @default.
• W2073970536 date "1998-05-01" @default.
• W2073970536 modified "2023-10-14" @default.
• W2073970536 title "Effects and Metabolism of Steroid Hormones in Human Neuroblastoma Cells" @default.
• W2073970536 cites W1515892916 @default.
• W2073970536 cites W156899246 @default.
• W2073970536 cites W1639119719 @default.
• W2073970536 cites W1819608959 @default.
• W2073970536 cites W1963879539 @default.
• W2073970536 cites W1965003802 @default.
• W2073970536 cites W1968701814 @default.
• W2073970536 cites W1970539961 @default.
• W2073970536 cites W1975122487 @default.
• W2073970536 cites W1977296415 @default.
• W2073970536 cites W1979845383 @default.
• W2073970536 cites W1984496769 @default.
• W2073970536 cites W1988993069 @default.
• W2073970536 cites W2020913137 @default.
• W2073970536 cites W2022065845 @default.
• W2073970536 cites W2026201299 @default.
• W2073970536 cites W2032361181 @default.
• W2073970536 cites W2033765186 @default.
• W2073970536 cites W2048397842 @default.
• W2073970536 cites W2050156667 @default.
• W2073970536 cites W2051024082 @default.
• W2073970536 cites W2066171968 @default.
• W2073970536 cites W2070477531 @default.
• W2073970536 cites W2070584201 @default.
• W2073970536 cites W2078387780 @default.
• W2073970536 cites W2085631316 @default.
• W2073970536 cites W2103821930 @default.
• W2073970536 cites W2116419432 @default.
• W2073970536 cites W2132381192 @default.
• W2073970536 cites W2170735592 @default.
• W2073970536 cites W2171128838 @default.
• W2073970536 cites W2196542788 @default.
• W2073970536 cites W4240606373 @default.
• W2073970536 cites W4245900774 @default.
• W2073970536 doi "https://doi.org/10.1016/s0039-128x(98)00038-5" @default.
• W2073970536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9618781" @default.
• W2073970536 hasPublicationYear "1998" @default.
• W2073970536 type Work @default.
• W2073970536 sameAs 2073970536 @default.
• W2073970536 citedByCount "12" @default.
• W2073970536 countsByYear W20739705362016 @default.
• W2073970536 countsByYear W20739705362019 @default.
• W2073970536 countsByYear W20739705362020 @default.
• W2073970536 countsByYear W20739705362023 @default.
• W2073970536 crossrefType "journal-article" @default.
• W2073970536 hasAuthorship W2073970536A5000101718 @default.
• W2073970536 hasAuthorship W2073970536A5005948227 @default.
• W2073970536 hasAuthorship W2073970536A5009283840 @default.
• W2073970536 hasAuthorship W2073970536A5027154404 @default.
• W2073970536 hasAuthorship W2073970536A5044387326 @default.
• W2073970536 hasAuthorship W2073970536A5059962048 @default.
• W2073970536 hasAuthorship W2073970536A5088952771 @default.
• W2073970536 hasConcept C126322002 @default.
• W2073970536 hasConcept C134018914 @default.
• W2073970536 hasConcept C2776715637 @default.
• W2073970536 hasConcept C2776888042 @default.
• W2073970536 hasConcept C2780902042 @default.
• W2073970536 hasConcept C54355233 @default.
• W2073970536 hasConcept C55493867 @default.
• W2073970536 hasConcept C62112901 @default.
• W2073970536 hasConcept C71315377 @default.
• W2073970536 hasConcept C71924100 @default.
• W2073970536 hasConcept C79879829 @default.
• W2073970536 hasConcept C81885089 @default.
• W2073970536 hasConcept C86803240 @default.
• W2073970536 hasConcept C95444343 @default.
• W2073970536 hasConceptScore W2073970536C126322002 @default.
• W2073970536 hasConceptScore W2073970536C134018914 @default.
• W2073970536 hasConceptScore W2073970536C2776715637 @default.
• W2073970536 hasConceptScore W2073970536C2776888042 @default.
• W2073970536 hasConceptScore W2073970536C2780902042 @default.
• W2073970536 hasConceptScore W2073970536C54355233 @default.
• W2073970536 hasConceptScore W2073970536C55493867 @default.
• W2073970536 hasConceptScore W2073970536C62112901 @default.
• W2073970536 hasConceptScore W2073970536C71315377 @default.
• W2073970536 hasConceptScore W2073970536C71924100 @default.
• W2073970536 hasConceptScore W2073970536C79879829 @default.
• W2073970536 hasConceptScore W2073970536C81885089 @default.
• W2073970536 hasConceptScore W2073970536C86803240 @default.
• W2073970536 hasConceptScore W2073970536C95444343 @default.
• W2073970536 hasIssue "5-6" @default.
• W2073970536 hasLocation W20739705361 @default.
• W2073970536 hasLocation W20739705362 @default.
• W2073970536 hasOpenAccess W2073970536 @default.
• W2073970536 hasPrimaryLocation W20739705361 @default.
• W2073970536 hasRelatedWork W1147278612 @default.

• next