FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073978079> ?p ?o ?g. }

• W2073978079 endingPage "59" @default.
• W2073978079 startingPage "51" @default.
• W2073978079 abstract "An analysis of the complete Molluscum contagiosum virus (MCV-1) genome sequence revealed a 104-amino-acid open reading frame (MC148R) that is structurally related to the beta (CC) family of chemokines. The predicted MCV chemokine homolog (MCCH) has a deletion in the NH2-terminal activation domain, suggesting the absence of chemoattractant activity. The principal objectives of the present study were to determine whether: (i) MCCH is conserved in independent isolates of MCV-1 and MCV-2; (ii) MCCH mRNA is expressed in vivo; and (iii) the MCCH protein is secreted from mammalian cells. The nucleotide sequence of the MCCH gene locus was determined for 27 isolates of MCV-1 and 2 of MCV-2 obtained from 29 MCV-infected individuals. In each case, the characteristic CC sequence, the NH2-terminal deletion, and the length of the open reading frame were conserved, although there were some, mostly conservative, amino acid substitutions. Since MCV cannot be propagated in cell culture, mRNA was synthesized in vitro by the early transcription apparatus in purified MCV virions. MCCH RNA was amplified by RT-PCR; the sequence included the complete open reading frame and extended 40 to 50 nucleotides past the first poxviral termination signal (TTTTTNT). Similar RT-PCR results were obtained using total cellular RNA derived from MCV-infected tissue specimens. Finally, the MCCH open reading frame was expressed in a vaccinia virus vector and the predicted size polypeptide was secreted into the medium, as determined by Western blotting. Taken together, our data support the prediction that MCV expresses a secreted chemokine homolog that could antagonize the inflammatory response in vivo." @default.
• W2073978079 created "2016-06-24" @default.
• W2073978079 creator A5032895526 @default.
• W2073978079 creator A5035265346 @default.
• W2073978079 creator A5037813067 @default.
• W2073978079 creator A5039158164 @default.
• W2073978079 creator A5077370432 @default.
• W2073978079 date "1998-03-01" @default.
• W2073978079 modified "2023-10-15" @default.
• W2073978079 title "Chemokine Homolog of Molluscum Contagiosum Virus: Sequence Conservation and Expression" @default.
• W2073978079 cites W1550055395 @default.
• W2073978079 cites W1963696997 @default.
• W2073978079 cites W1965085113 @default.
• W2073978079 cites W1986911979 @default.
• W2073978079 cites W1996188270 @default.
• W2073978079 cites W2014048242 @default.
• W2073978079 cites W2023590791 @default.
• W2073978079 cites W2026580851 @default.
• W2073978079 cites W2027344845 @default.
• W2073978079 cites W2049868653 @default.
• W2073978079 cites W2052537464 @default.
• W2073978079 cites W2056596431 @default.
• W2073978079 cites W2060277879 @default.
• W2073978079 cites W2080011897 @default.
• W2073978079 cites W2084106399 @default.
• W2073978079 cites W2085193742 @default.
• W2073978079 cites W2090719106 @default.
• W2073978079 cites W2097013351 @default.
• W2073978079 cites W2118104083 @default.
• W2073978079 cites W2130412866 @default.
• W2073978079 cites W2145927389 @default.
• W2073978079 cites W2158368514 @default.
• W2073978079 cites W2159163386 @default.
• W2073978079 cites W4232488115 @default.
• W2073978079 cites W4246290384 @default.
• W2073978079 cites W4293021495 @default.
• W2073978079 cites W4296792904 @default.
• W2073978079 cites W4382787168 @default.
• W2073978079 doi "https://doi.org/10.1006/viro.1997.9001" @default.
• W2073978079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9501046" @default.
• W2073978079 hasPublicationYear "1998" @default.
• W2073978079 type Work @default.
• W2073978079 sameAs 2073978079 @default.
• W2073978079 citedByCount "31" @default.
• W2073978079 countsByYear W20739780792013 @default.
• W2073978079 countsByYear W20739780792014 @default.
• W2073978079 countsByYear W20739780792016 @default.
• W2073978079 countsByYear W20739780792019 @default.
• W2073978079 countsByYear W20739780792020 @default.
• W2073978079 crossrefType "journal-article" @default.
• W2073978079 hasAuthorship W2073978079A5032895526 @default.
• W2073978079 hasAuthorship W2073978079A5035265346 @default.
• W2073978079 hasAuthorship W2073978079A5037813067 @default.
• W2073978079 hasAuthorship W2073978079A5039158164 @default.
• W2073978079 hasAuthorship W2073978079A5077370432 @default.
• W2073978079 hasBestOaLocation W20739780791 @default.
• W2073978079 hasConcept C104317684 @default.
• W2073978079 hasConcept C105580179 @default.
• W2073978079 hasConcept C13373296 @default.
• W2073978079 hasConcept C153911025 @default.
• W2073978079 hasConcept C159047783 @default.
• W2073978079 hasConcept C167625842 @default.
• W2073978079 hasConcept C170493617 @default.
• W2073978079 hasConcept C2522874641 @default.
• W2073978079 hasConcept C47289529 @default.
• W2073978079 hasConcept C54355233 @default.
• W2073978079 hasConcept C61053724 @default.
• W2073978079 hasConcept C67705224 @default.
• W2073978079 hasConcept C84148353 @default.
• W2073978079 hasConcept C86803240 @default.
• W2073978079 hasConceptScore W2073978079C104317684 @default.
• W2073978079 hasConceptScore W2073978079C105580179 @default.
• W2073978079 hasConceptScore W2073978079C13373296 @default.
• W2073978079 hasConceptScore W2073978079C153911025 @default.
• W2073978079 hasConceptScore W2073978079C159047783 @default.
• W2073978079 hasConceptScore W2073978079C167625842 @default.
• W2073978079 hasConceptScore W2073978079C170493617 @default.
• W2073978079 hasConceptScore W2073978079C2522874641 @default.
• W2073978079 hasConceptScore W2073978079C47289529 @default.
• W2073978079 hasConceptScore W2073978079C54355233 @default.
• W2073978079 hasConceptScore W2073978079C61053724 @default.
• W2073978079 hasConceptScore W2073978079C67705224 @default.
• W2073978079 hasConceptScore W2073978079C84148353 @default.
• W2073978079 hasConceptScore W2073978079C86803240 @default.
• W2073978079 hasIssue "1" @default.
• W2073978079 hasLocation W20739780791 @default.
• W2073978079 hasLocation W20739780792 @default.
• W2073978079 hasOpenAccess W2073978079 @default.
• W2073978079 hasPrimaryLocation W20739780791 @default.
• W2073978079 hasRelatedWork W1767767984 @default.
• W2073978079 hasRelatedWork W1894156927 @default.
• W2073978079 hasRelatedWork W1921711018 @default.
• W2073978079 hasRelatedWork W1968849150 @default.
• W2073978079 hasRelatedWork W2086454943 @default.
• W2073978079 hasRelatedWork W2090317768 @default.
• W2073978079 hasRelatedWork W2139071195 @default.
• W2073978079 hasRelatedWork W2303297055 @default.
• W2073978079 hasRelatedWork W2357489557 @default.

• next