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- W2073979191 abstract "Macrocyclization from the phosphotyrosyl (pTyr) mimetic's β-position has previously been shown to enhance Grb2 SH2 domain-binding affinity of phosphonate-based analogues. The current study examined the effects of such macrocyclization using a dicarboxymethyl-based pTyr mimetic. In extracellular assays affinity was enhanced approximately 5-fold relative to an open-chain congener. Enhancement was also observed in whole-cell assays examining blockade of Grb2 binding to the erbB-2 protein-tyrosine kinase." @default.
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- W2073979191 date "2004-03-11" @default.
- W2073979191 modified "2023-09-25" @default.
- W2073979191 title "Macrocyclization in the Design of Non-Phosphorus-Containing Grb2 SH2 Domain-Binding Ligands" @default.
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- W2073979191 doi "https://doi.org/10.1021/jm030510e" @default.
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