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- W2073995152 abstract "Members of the transforming growth factor-beta (TGF-beta) family of ligands exhibit potent growth-suppressive and/or apoptosis-inducing effects on different types of cells. They perform essential roles in the elimination of damaged or abnormal cells from healthy tissues. On the other hand, TGF-betas have also been shown to act as tumor-promoting cytokines in a number of malignancies that are capable of stimulating extracellular matrix production, cell migration, invasion, angiogenesis, and immune suppression. Dissecting the complex, multifaceted roles of different TGF-beta-related peptides especially during the development of pathological conditions and in carcinogenesis is an area of continuous research and development. The characterization of EGF-CFC proteins as essential co-receptors that contribute to the modulation of the physiological activities of some of the TGF-beta ligands will be beneficial for future medical research and the adaptation and possible readjustment of currently applied therapeutic regimes." @default.
- W2073995152 created "2016-06-24" @default.
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- W2073995152 date "2005-11-01" @default.
- W2073995152 modified "2023-10-03" @default.
- W2073995152 title "Modulation of TGF-β signaling by EGF-CFC proteins" @default.
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- W2073995152 doi "https://doi.org/10.1016/j.yexcr.2005.07.023" @default.
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