FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073996957> ?p ?o ?g. }

• W2073996957 endingPage "3205" @default.
• W2073996957 startingPage "3197" @default.
• W2073996957 abstract "Hematopoietic stem and progenitor cells with inactivated Fanconi anemia (FA) genes, FANCA and FANCC, are hypersensitive to inflammatory cytokines. One of these, tumor necrosis factor α (TNF-α), is also overproduced by FA mononuclear phagocytes in response to certain Toll-like receptor (TLR) agonists, creating an autoinhibitory loop that may contribute to the pathogenesis of progressive bone marrow (BM) failure and selection of TNF-α-resistant leukemic stem cell clones. In macrophages, the TNF-α overproduction phenotype depends on p38 mitogen-activated protein kinase (MAPK), an enzyme also known to induce expression of other inflammatory cytokines, including interleukin 1β (IL-1β). Reasoning that IL-1β might be involved in a like autoinhibitory loop, we determined that (1) TLR activation of FANCA- and FANCC-deficient macrophages induced overproduction of both TNF-α and IL-1β in a p38-dependent manner; (2) exposure of Fancc-deficient BM progenitors to IL-1β potently suppressed the expansion of multipotent progenitor cells in vitro; and (3) although TNF-α overexpression in FA cells is controlled posttranscriptionally by the p38 substrate MAPKAPK-2, p38-dependent overproduction of IL-1β is controlled transcriptionally. We suggest that multiple inflammatory cytokines overproduced by FANCA- and FANCC-deficient mononuclear phagocytes may contribute to the progressive BM failure that characterizes FA, and that to achieve suppression of this proinflammatory state, p38 is a more promising molecular therapeutic target than either IL-1β or TNF-α alone." @default.
• W2073996957 created "2016-06-24" @default.
• W2073996957 creator A5024713525 @default.
• W2073996957 creator A5033631341 @default.
• W2073996957 creator A5043574936 @default.
• W2073996957 creator A5047703070 @default.
• W2073996957 creator A5056849436 @default.
• W2073996957 creator A5076250383 @default.
• W2073996957 date "2013-10-31" @default.
• W2073996957 modified "2023-10-13" @default.
• W2073996957 title "FANCA and FANCC modulate TLR and p38 MAPK–dependent expression of IL-1β in macrophages" @default.
• W2073996957 cites W1481604795 @default.
• W2073996957 cites W1521417371 @default.
• W2073996957 cites W1554788037 @default.
• W2073996957 cites W1742238700 @default.
• W2073996957 cites W1856799309 @default.
• W2073996957 cites W1968633443 @default.
• W2073996957 cites W1981837371 @default.
• W2073996957 cites W1986331600 @default.
• W2073996957 cites W1986890123 @default.
• W2073996957 cites W2004949125 @default.
• W2073996957 cites W2005504069 @default.
• W2073996957 cites W2011319917 @default.
• W2073996957 cites W2020144578 @default.
• W2073996957 cites W2021731035 @default.
• W2073996957 cites W2023843593 @default.
• W2073996957 cites W2024073282 @default.
• W2073996957 cites W2031746309 @default.
• W2073996957 cites W2035003065 @default.
• W2073996957 cites W2036716410 @default.
• W2073996957 cites W2041012906 @default.
• W2073996957 cites W2043051674 @default.
• W2073996957 cites W2046872014 @default.
• W2073996957 cites W2048442967 @default.
• W2073996957 cites W2048446461 @default.
• W2073996957 cites W2050519121 @default.
• W2073996957 cites W2056666823 @default.
• W2073996957 cites W2056907950 @default.
• W2073996957 cites W2056944294 @default.
• W2073996957 cites W2061003965 @default.
• W2073996957 cites W2074529613 @default.
• W2073996957 cites W2074821144 @default.
• W2073996957 cites W2078142614 @default.
• W2073996957 cites W2079661961 @default.
• W2073996957 cites W2086655427 @default.
• W2073996957 cites W2095313016 @default.
• W2073996957 cites W2102991803 @default.
• W2073996957 cites W2108244937 @default.
• W2073996957 cites W2114449244 @default.
• W2073996957 cites W2115110568 @default.
• W2073996957 cites W2130253923 @default.
• W2073996957 cites W2134007048 @default.
• W2073996957 cites W2137230390 @default.
• W2073996957 cites W2138336407 @default.
• W2073996957 cites W2151206132 @default.
• W2073996957 cites W2154325818 @default.
• W2073996957 cites W2165275387 @default.
• W2073996957 cites W2167464044 @default.
• W2073996957 cites W2168104423 @default.
• W2073996957 cites W2171806736 @default.
• W2073996957 cites W2411183007 @default.
• W2073996957 cites W4211217520 @default.
• W2073996957 cites W4313335068 @default.
• W2073996957 doi "https://doi.org/10.1182/blood-2013-02-484816" @default.
• W2073996957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3814736" @default.
• W2073996957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24046015" @default.
• W2073996957 hasPublicationYear "2013" @default.
• W2073996957 type Work @default.
• W2073996957 sameAs 2073996957 @default.
• W2073996957 citedByCount "26" @default.
• W2073996957 countsByYear W20739969572014 @default.
• W2073996957 countsByYear W20739969572015 @default.
• W2073996957 countsByYear W20739969572016 @default.
• W2073996957 countsByYear W20739969572017 @default.
• W2073996957 countsByYear W20739969572018 @default.
• W2073996957 countsByYear W20739969572019 @default.
• W2073996957 countsByYear W20739969572020 @default.
• W2073996957 countsByYear W20739969572021 @default.
• W2073996957 countsByYear W20739969572022 @default.
• W2073996957 countsByYear W20739969572023 @default.
• W2073996957 crossrefType "journal-article" @default.
• W2073996957 hasAuthorship W2073996957A5024713525 @default.
• W2073996957 hasAuthorship W2073996957A5033631341 @default.
• W2073996957 hasAuthorship W2073996957A5043574936 @default.
• W2073996957 hasAuthorship W2073996957A5047703070 @default.
• W2073996957 hasAuthorship W2073996957A5056849436 @default.
• W2073996957 hasAuthorship W2073996957A5076250383 @default.
• W2073996957 hasBestOaLocation W20739969571 @default.
• W2073996957 hasConcept C104317684 @default.
• W2073996957 hasConcept C109159458 @default.
• W2073996957 hasConcept C134935766 @default.
• W2073996957 hasConcept C164027704 @default.
• W2073996957 hasConcept C17991360 @default.
• W2073996957 hasConcept C201750760 @default.
• W2073996957 hasConcept C203014093 @default.
• W2073996957 hasConcept C2776914184 @default.
• W2073996957 hasConcept C2778124228 @default.
• W2073996957 hasConcept C2778993383 @default.

• next