FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073997943> ?p ?o ?g. }

• W2073997943 endingPage "1270" @default.
• W2073997943 startingPage "1264" @default.
• W2073997943 abstract "The present study was designed to examine the cellular localization and biosynthetic machinery of the broad-spectrum excitatory amino acid receptor antagonist kynurenic acid in the lesioned rat hippocampus. Seven days after an intrahippocampal injection of 120 nmol quinolinic acid, which causes massive neurodegeneration in the dorsal hippocampus, kynurenic acid tissue levels and the activity of kynurenic acid's anabolic enzyme, kynurenine aminotransferase, were increased by 92% and 67%, respectively, as compared to controls. The steady-state levels of extracellular kynurenic acid, examined by microdialysis in unanaesthetized rats, were also increased in the lesioned tissue (from 93.6 +/- 10.2 to 207.6 +/- 18.6 fmol/30 microl dialysate). Using microdialysis, three compounds which are known to decrease kynurenic acid production from its bioprecursor l-kynurenine in brain slices and in vivo were tested for their ability to reduce the levels of endogenous kynurenic acid. In unlesioned tissue, aminooxyacetic acid (300 microM), veratridine (50 microM) and glutamate (5 mM), all administered through the dialysis probe, decreased extracellular kynurenic acid concentrations by 30 - 40%, i.e. to a lesser degree than in previous experiments in which kynurenine was used as a bioprecursor. Only the effect of veratridine was abolished in the quinolinate-lesioned hippocampus. These data indicate that kynurenic acid is produced in and liberated from astrocytes, and that aminooxyacetic acid and glutamate (but not veratridine) exert their action by directly affecting glial kynurenic acid biosynthesis. The results also suggest the existence of two distinct intracellular kynurenic acid pools, which are responsible for kynurenic acid storage and rapid kynurenic acid mobilization, respectively. Taken together, these features of kynurenic acid neurobiology may be of relevance in the control of excitatory amino acid receptor function under physiological and pathological conditions." @default.
• W2073997943 created "2016-06-24" @default.
• W2073997943 creator A5047555416 @default.
• W2073997943 creator A5049171963 @default.
• W2073997943 creator A5078829134 @default.
• W2073997943 creator A5086132034 @default.
• W2073997943 date "1992-12-01" @default.
• W2073997943 modified "2023-10-03" @default.
• W2073997943 title "Kynurenic Acid in the Quinolinate-lesioned Rat Hippocampus: Studies<i>In Vitro</i>and<i>In Vivo</i>" @default.
• W2073997943 cites W1775749144 @default.
• W2073997943 cites W1868733321 @default.
• W2073997943 cites W1969388943 @default.
• W2073997943 cites W1969924393 @default.
• W2073997943 cites W1985118788 @default.
• W2073997943 cites W1985615482 @default.
• W2073997943 cites W1993419219 @default.
• W2073997943 cites W1995814885 @default.
• W2073997943 cites W1996465026 @default.
• W2073997943 cites W2006207643 @default.
• W2073997943 cites W2007418463 @default.
• W2073997943 cites W2012058619 @default.
• W2073997943 cites W2013236786 @default.
• W2073997943 cites W2022889768 @default.
• W2073997943 cites W2023811880 @default.
• W2073997943 cites W2029753749 @default.
• W2073997943 cites W2031618954 @default.
• W2073997943 cites W2034230809 @default.
• W2073997943 cites W2044065510 @default.
• W2073997943 cites W2046678045 @default.
• W2073997943 cites W2049608409 @default.
• W2073997943 cites W2051353156 @default.
• W2073997943 cites W2051950936 @default.
• W2073997943 cites W2052379582 @default.
• W2073997943 cites W2054469665 @default.
• W2073997943 cites W2054573921 @default.
• W2073997943 cites W2055623573 @default.
• W2073997943 cites W2057019886 @default.
• W2073997943 cites W2062156977 @default.
• W2073997943 cites W2067494870 @default.
• W2073997943 cites W2070662771 @default.
• W2073997943 cites W2090352316 @default.
• W2073997943 cites W2090359611 @default.
• W2073997943 cites W2091578245 @default.
• W2073997943 cites W2126390473 @default.
• W2073997943 cites W2145302977 @default.
• W2073997943 cites W2169953089 @default.
• W2073997943 cites W2275222709 @default.
• W2073997943 cites W4293247451 @default.
• W2073997943 doi "https://doi.org/10.1111/j.1460-9568.1992.tb00152.x" @default.
• W2073997943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12106390" @default.
• W2073997943 hasPublicationYear "1992" @default.
• W2073997943 type Work @default.
• W2073997943 sameAs 2073997943 @default.
• W2073997943 citedByCount "69" @default.
• W2073997943 countsByYear W20739979432012 @default.
• W2073997943 countsByYear W20739979432013 @default.
• W2073997943 countsByYear W20739979432016 @default.
• W2073997943 countsByYear W20739979432022 @default.
• W2073997943 crossrefType "journal-article" @default.
• W2073997943 hasAuthorship W2073997943A5047555416 @default.
• W2073997943 hasAuthorship W2073997943A5049171963 @default.
• W2073997943 hasAuthorship W2073997943A5078829134 @default.
• W2073997943 hasAuthorship W2073997943A5086132034 @default.
• W2073997943 hasConcept C126322002 @default.
• W2073997943 hasConcept C170493617 @default.
• W2073997943 hasConcept C181199279 @default.
• W2073997943 hasConcept C185592680 @default.
• W2073997943 hasConcept C2776108384 @default.
• W2073997943 hasConcept C2776627618 @default.
• W2073997943 hasConcept C2776706248 @default.
• W2073997943 hasConcept C2776841986 @default.
• W2073997943 hasConcept C2777503454 @default.
• W2073997943 hasConcept C2777896816 @default.
• W2073997943 hasConcept C28406088 @default.
• W2073997943 hasConcept C2910635417 @default.
• W2073997943 hasConcept C50156730 @default.
• W2073997943 hasConcept C515207424 @default.
• W2073997943 hasConcept C55493867 @default.
• W2073997943 hasConcept C61174792 @default.
• W2073997943 hasConcept C71924100 @default.
• W2073997943 hasConcept C86803240 @default.
• W2073997943 hasConcept C98274493 @default.
• W2073997943 hasConceptScore W2073997943C126322002 @default.
• W2073997943 hasConceptScore W2073997943C170493617 @default.
• W2073997943 hasConceptScore W2073997943C181199279 @default.
• W2073997943 hasConceptScore W2073997943C185592680 @default.
• W2073997943 hasConceptScore W2073997943C2776108384 @default.
• W2073997943 hasConceptScore W2073997943C2776627618 @default.
• W2073997943 hasConceptScore W2073997943C2776706248 @default.
• W2073997943 hasConceptScore W2073997943C2776841986 @default.
• W2073997943 hasConceptScore W2073997943C2777503454 @default.
• W2073997943 hasConceptScore W2073997943C2777896816 @default.
• W2073997943 hasConceptScore W2073997943C28406088 @default.
• W2073997943 hasConceptScore W2073997943C2910635417 @default.
• W2073997943 hasConceptScore W2073997943C50156730 @default.
• W2073997943 hasConceptScore W2073997943C515207424 @default.
• W2073997943 hasConceptScore W2073997943C55493867 @default.
• W2073997943 hasConceptScore W2073997943C61174792 @default.

• next