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- W2074001520 abstract "The secretory pathway provides a physical route through which only correctly folded gene products are delivered to the eukaryotic cell surface. The efficiency of endoplasmic reticulum (ER)-associated degradation (ERAD), which orchestrates the clearance of structurally aberrant proteins under basal conditions, is boosted by the unfolded protein response (UPR) as one of several means to relieve ER stress. However, the underlying mechanism that links the two systems in higher eukaryotes has remained elusive. Herein, the results of transient expression, RNAi-mediated knockdown and functional studies demonstrate that the transcriptional elevation of EDEM1 boosts the efficiency of glycoprotein ERAD through the formation of a complex that suppresses the proteolytic downregulation of ER mannosidase I (ERManI). The results of site-directed mutagenesis indicate that this capacity does not require that EDEM1 possess inherent mannosidase activity. A model is proposed in which ERManI, by functioning as a downstream effector target of EDEM1, represents a checkpoint activation paradigm by which the mammalian UPR coordinates the boosting of ERAD." @default.
- W2074001520 created "2016-06-24" @default.
- W2074001520 creator A5012582534 @default.
- W2074001520 creator A5024936464 @default.
- W2074001520 creator A5077804522 @default.
- W2074001520 date "2009-04-01" @default.
- W2074001520 modified "2023-10-15" @default.
- W2074001520 title "The mammalian UPR boosts glycoprotein ERAD by suppressing the proteolytic downregulation of ER mannosidase I" @default.
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- W2074001520 doi "https://doi.org/10.1242/jcs.037291" @default.
- W2074001520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2720930" @default.
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