Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074001528> ?p ?o ?g. }
- W2074001528 endingPage "753" @default.
- W2074001528 startingPage "741" @default.
- W2074001528 abstract "Rationale Airway remodeling is believed to be important in the pathophysiology of asthma, and myofibroblasts are increased in the airways of asthmatic individuals 24 h after allergen challenge. Leukotriene receptor antagonists exert antiinflammatory activity in asthma, but it is unknown whether they influence indices of airway remodeling. In the present study, we evaluated the effect of montelukast on airway myofibroblasts following low-dose allergen challenge (LDAC). Methods Stable subjects with mild asthma were included in a two-center, randomized, parallel-group study. A 2-week run-in period was followed by LDAC and endobronchial biopsy. Subjects were then randomized to receive either montelukast, 10 mg/d, or placebo (n = 10 in each group) for 8 weeks in a double-blind manner; at the end of the treatment period, subjects underwent a second LDAC and endobronchial biopsy. The effect of treatment on myofibroblasts, fibroblasts, and inflammatory cells was examined using electron microscopy techniques. Results Treatment with montelukast showed no significant difference by comparison with placebo but did show a significant within-group treatment-related decrease in airway wall myofibroblasts not seen in the placebo group. In addition, the montelukast-treated group also showed a significant within-group reduction in lymphomononuclear cells and increased neutrophils. Conclusions The results suggest that montelukast has an inhibitory effect on airway structural cells that play a key role in airway remodeling in allergic airway inflammation, and that montelukast may be a useful therapy to attenuate airway remodeling in asthma. Airway remodeling is believed to be important in the pathophysiology of asthma, and myofibroblasts are increased in the airways of asthmatic individuals 24 h after allergen challenge. Leukotriene receptor antagonists exert antiinflammatory activity in asthma, but it is unknown whether they influence indices of airway remodeling. In the present study, we evaluated the effect of montelukast on airway myofibroblasts following low-dose allergen challenge (LDAC). Stable subjects with mild asthma were included in a two-center, randomized, parallel-group study. A 2-week run-in period was followed by LDAC and endobronchial biopsy. Subjects were then randomized to receive either montelukast, 10 mg/d, or placebo (n = 10 in each group) for 8 weeks in a double-blind manner; at the end of the treatment period, subjects underwent a second LDAC and endobronchial biopsy. The effect of treatment on myofibroblasts, fibroblasts, and inflammatory cells was examined using electron microscopy techniques. Treatment with montelukast showed no significant difference by comparison with placebo but did show a significant within-group treatment-related decrease in airway wall myofibroblasts not seen in the placebo group. In addition, the montelukast-treated group also showed a significant within-group reduction in lymphomononuclear cells and increased neutrophils. The results suggest that montelukast has an inhibitory effect on airway structural cells that play a key role in airway remodeling in allergic airway inflammation, and that montelukast may be a useful therapy to attenuate airway remodeling in asthma." @default.
- W2074001528 created "2016-06-24" @default.
- W2074001528 creator A5000657922 @default.
- W2074001528 creator A5005295653 @default.
- W2074001528 creator A5040151362 @default.
- W2074001528 creator A5049410387 @default.
- W2074001528 creator A5081195905 @default.
- W2074001528 creator A5084946954 @default.
- W2074001528 creator A5087705837 @default.
- W2074001528 date "2006-09-01" @default.
- W2074001528 modified "2023-10-14" @default.
- W2074001528 title "Montelukast Treatment Attenuates the Increase in Myofibroblasts Following Low-Dose Allergen Challenge" @default.
- W2074001528 cites W1537391383 @default.
- W2074001528 cites W1827989790 @default.
- W2074001528 cites W1900945426 @default.
- W2074001528 cites W1965794676 @default.
- W2074001528 cites W1967265143 @default.
- W2074001528 cites W1968898221 @default.
- W2074001528 cites W1971254063 @default.
- W2074001528 cites W1988961120 @default.
- W2074001528 cites W1989260226 @default.
- W2074001528 cites W1991246311 @default.
- W2074001528 cites W1992781686 @default.
- W2074001528 cites W1993205016 @default.
- W2074001528 cites W1998077153 @default.
- W2074001528 cites W1998461490 @default.
- W2074001528 cites W2012813253 @default.
- W2074001528 cites W2014305132 @default.
- W2074001528 cites W2017376355 @default.
- W2074001528 cites W2028798638 @default.
- W2074001528 cites W2028878799 @default.
- W2074001528 cites W2029251290 @default.
- W2074001528 cites W2031274702 @default.
- W2074001528 cites W2035956731 @default.
- W2074001528 cites W2036759594 @default.
- W2074001528 cites W2044164946 @default.
- W2074001528 cites W2046661997 @default.
- W2074001528 cites W2047908260 @default.
- W2074001528 cites W2049796670 @default.
- W2074001528 cites W2060475913 @default.
- W2074001528 cites W2063203571 @default.
- W2074001528 cites W2078677353 @default.
- W2074001528 cites W2080529843 @default.
- W2074001528 cites W2086394533 @default.
- W2074001528 cites W2086948000 @default.
- W2074001528 cites W2090463334 @default.
- W2074001528 cites W2091193900 @default.
- W2074001528 cites W2091456991 @default.
- W2074001528 cites W2092396047 @default.
- W2074001528 cites W2092661479 @default.
- W2074001528 cites W2096242114 @default.
- W2074001528 cites W2097490698 @default.
- W2074001528 cites W2102416816 @default.
- W2074001528 cites W2104237019 @default.
- W2074001528 cites W2105795870 @default.
- W2074001528 cites W2110799130 @default.
- W2074001528 cites W2112670807 @default.
- W2074001528 cites W2116594128 @default.
- W2074001528 cites W2117159720 @default.
- W2074001528 cites W2121464855 @default.
- W2074001528 cites W2121506556 @default.
- W2074001528 cites W2127751349 @default.
- W2074001528 cites W2130098255 @default.
- W2074001528 cites W2131131671 @default.
- W2074001528 cites W2131445772 @default.
- W2074001528 cites W2133387174 @default.
- W2074001528 cites W2137401824 @default.
- W2074001528 cites W2148102009 @default.
- W2074001528 cites W2148493195 @default.
- W2074001528 cites W2152879293 @default.
- W2074001528 cites W2153381449 @default.
- W2074001528 cites W2157943009 @default.
- W2074001528 cites W2160596532 @default.
- W2074001528 cites W2160698607 @default.
- W2074001528 cites W2167730388 @default.
- W2074001528 cites W2167956058 @default.
- W2074001528 cites W2181517072 @default.
- W2074001528 cites W2615778352 @default.
- W2074001528 cites W2766240094 @default.
- W2074001528 cites W4236639597 @default.
- W2074001528 cites W4239635933 @default.
- W2074001528 doi "https://doi.org/10.1378/chest.130.3.741" @default.
- W2074001528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16963671" @default.
- W2074001528 hasPublicationYear "2006" @default.
- W2074001528 type Work @default.
- W2074001528 sameAs 2074001528 @default.
- W2074001528 citedByCount "61" @default.
- W2074001528 countsByYear W20740015282012 @default.
- W2074001528 countsByYear W20740015282013 @default.
- W2074001528 countsByYear W20740015282014 @default.
- W2074001528 countsByYear W20740015282015 @default.
- W2074001528 countsByYear W20740015282016 @default.
- W2074001528 countsByYear W20740015282017 @default.
- W2074001528 countsByYear W20740015282018 @default.
- W2074001528 countsByYear W20740015282019 @default.
- W2074001528 countsByYear W20740015282020 @default.
- W2074001528 countsByYear W20740015282021 @default.
- W2074001528 countsByYear W20740015282022 @default.