FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074002006> ?p ?o ?g. }

• W2074002006 endingPage "398" @default.
• W2074002006 startingPage "389" @default.
• W2074002006 abstract "The objective of this study was to evaluate the efficacy and safety of low doses (50 and 100 microg b.i.d.) of hydrofluoroalkane-134a (HFA) beclomethasone dipropionate (BDP) extrafine aerosol in improving asthma control. Reformulation of BDP in a new chlorofluorocarbon (CFC)-free propellant (HFA) has produced an extrafine aerosol with increased delivery of the drug to the airways of the lung. The study population comprised 270 steroid-naive patients with mild to moderate asthma (mean baseline forced expiratory volume in 1 sec [FEV1] as a percentage of predicted normal of 65%-85%). This was a 6-week, blinded, placebo-controlled, multicenter study. Patients were randomized to receive 50 or 100 microg b.i.d. HFA-BDP or HFA-placebo. Treatment with either 50 or 100 microg b.i.d. HFA-BDP resulted in a significantly greater improvement compared with placebo in FEV1 (mean change from baseline as percentage of predicted normal of 6.7%, 8.6%, and 0.4%, respectively; p < or = 0.01 active treatment groups vs. placebo), with a significant trend toward increasing improvement with increasing doses (p < or = 0.0001). Treatment also resulted in significantly greater mean changes from baseline in morning peak expiratory flow compared with placebo (29.5, 33.8, and 5.0 L/min, respectively; p < or = 0.01 active treatment groups vs. placebo). All other pulmonary function and asthma symptom measures supported these data. The study treatments were well tolerated. These results show that low doses of HFA-BDP extrafine aerosol effectively improve asthma control in adult patients with mild to moderate asthma. However, it is important that inhaled corticosteroid therapy is still given at a dose high enough to control airway inflammation as well as asthma symptoms." @default.
• W2074002006 created "2016-06-24" @default.
• W2074002006 creator A5016731920 @default.
• W2074002006 creator A5050920834 @default.
• W2074002006 creator A5056860189 @default.
• W2074002006 creator A5089114189 @default.
• W2074002006 date "2000-01-01" @default.
• W2074002006 modified "2023-09-27" @default.
• W2074002006 title "Effectiveness of Low Doses (50 and 100 μg b.i.d.) of Beclomethasone Dipropionate Delivered as a CFC-Free Extrafine Aerosol in Adults with Mild to Moderate Asthma" @default.
• W2074002006 cites W1875328952 @default.
• W2074002006 cites W1986186916 @default.
• W2074002006 cites W2001314181 @default.
• W2074002006 cites W2045943883 @default.
• W2074002006 cites W2109806344 @default.
• W2074002006 cites W2114437823 @default.
• W2074002006 cites W2122956855 @default.
• W2074002006 cites W2131336668 @default.
• W2074002006 cites W2141470766 @default.
• W2074002006 cites W4299648375 @default.
• W2074002006 doi "https://doi.org/10.3109/02770900009055464" @default.
• W2074002006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10983616" @default.
• W2074002006 hasPublicationYear "2000" @default.
• W2074002006 type Work @default.
• W2074002006 sameAs 2074002006 @default.
• W2074002006 citedByCount "15" @default.
• W2074002006 countsByYear W20740020062020 @default.
• W2074002006 crossrefType "journal-article" @default.
• W2074002006 hasAuthorship W2074002006A5016731920 @default.
• W2074002006 hasAuthorship W2074002006A5050920834 @default.
• W2074002006 hasAuthorship W2074002006A5056860189 @default.
• W2074002006 hasAuthorship W2074002006A5089114189 @default.
• W2074002006 hasConcept C121332964 @default.
• W2074002006 hasConcept C126322002 @default.
• W2074002006 hasConcept C142724271 @default.
• W2074002006 hasConcept C153294291 @default.
• W2074002006 hasConcept C19720800 @default.
• W2074002006 hasConcept C204787440 @default.
• W2074002006 hasConcept C27081682 @default.
• W2074002006 hasConcept C2776042228 @default.
• W2074002006 hasConcept C2776178081 @default.
• W2074002006 hasConcept C2776804153 @default.
• W2074002006 hasConcept C2776954882 @default.
• W2074002006 hasConcept C2777714996 @default.
• W2074002006 hasConcept C2777992530 @default.
• W2074002006 hasConcept C2779017260 @default.
• W2074002006 hasConcept C2908647359 @default.
• W2074002006 hasConcept C42219234 @default.
• W2074002006 hasConcept C71924100 @default.
• W2074002006 hasConcept C99454951 @default.
• W2074002006 hasConceptScore W2074002006C121332964 @default.
• W2074002006 hasConceptScore W2074002006C126322002 @default.
• W2074002006 hasConceptScore W2074002006C142724271 @default.
• W2074002006 hasConceptScore W2074002006C153294291 @default.
• W2074002006 hasConceptScore W2074002006C19720800 @default.
• W2074002006 hasConceptScore W2074002006C204787440 @default.
• W2074002006 hasConceptScore W2074002006C27081682 @default.
• W2074002006 hasConceptScore W2074002006C2776042228 @default.
• W2074002006 hasConceptScore W2074002006C2776178081 @default.
• W2074002006 hasConceptScore W2074002006C2776804153 @default.
• W2074002006 hasConceptScore W2074002006C2776954882 @default.
• W2074002006 hasConceptScore W2074002006C2777714996 @default.
• W2074002006 hasConceptScore W2074002006C2777992530 @default.
• W2074002006 hasConceptScore W2074002006C2779017260 @default.
• W2074002006 hasConceptScore W2074002006C2908647359 @default.
• W2074002006 hasConceptScore W2074002006C42219234 @default.
• W2074002006 hasConceptScore W2074002006C71924100 @default.
• W2074002006 hasConceptScore W2074002006C99454951 @default.
• W2074002006 hasIssue "5" @default.
• W2074002006 hasLocation W20740020061 @default.
• W2074002006 hasLocation W20740020062 @default.
• W2074002006 hasOpenAccess W2074002006 @default.
• W2074002006 hasPrimaryLocation W20740020061 @default.
• W2074002006 hasRelatedWork W1988681733 @default.
• W2074002006 hasRelatedWork W2001001215 @default.
• W2074002006 hasRelatedWork W2005158361 @default.
• W2074002006 hasRelatedWork W2034085653 @default.
• W2074002006 hasRelatedWork W2101172321 @default.
• W2074002006 hasRelatedWork W2114437823 @default.
• W2074002006 hasRelatedWork W2117401654 @default.
• W2074002006 hasRelatedWork W2404822382 @default.
• W2074002006 hasRelatedWork W2411233343 @default.
• W2074002006 hasRelatedWork W4249858658 @default.
• W2074002006 hasVolume "37" @default.
• W2074002006 isParatext "false" @default.
• W2074002006 isRetracted "false" @default.
• W2074002006 magId "2074002006" @default.
• W2074002006 workType "article" @default.