Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074003071> ?p ?o ?g. }
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- W2074003071 startingPage "1090" @default.
- W2074003071 abstract "The IL-23/Th17 pathway has recently been identified to play a critical role in a number of chronic inflammatory diseases including inflammatory bowel disease (IBD). The identification in IBD patients of associations in IL23R and regions that include other genes in the IL-23/Th17 pathway has highlighted the importance of proper IL-23/Th17 pathway regulation in intestinal immune homeostasis. IL-23 plays a role in CD4+ Th17 lineage cells, characterized by IL-17 secretion and the expression of the transcription factor retinoic acid-related orphan receptor (ROR)γτ, and in other immune and nonimmune cells. The balance between effector T cell subsets, such as Th17 cells, and CD4+ T regulatory subsets is finely regulated; dysregulation of this balance can lead to inflammation and autoimmunity. As such, the IL-23/Th17 pathway contributes to immune responses that play a role in defenses to microbial infection, as well as in the intestinal inflammation observed in both animal models of colitis and human IBD." @default.
- W2074003071 created "2016-06-24" @default.
- W2074003071 creator A5012477767 @default.
- W2074003071 creator A5080459091 @default.
- W2074003071 date "2009-07-01" @default.
- W2074003071 modified "2023-09-27" @default.
- W2074003071 title "Interleukin-23/Th17 pathways and inflammatory bowel disease" @default.
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