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• W2074003525 abstract "A series of natural and synthetic piperine amides were evaluated for activity on the human TRPV1 expressed in HEK293 cells. The agonistic effect of piperine amides was mainly dependent on the length of the carbon chain. Structural changes of double bonds and stereochemistry in the aliphatic chain of these compounds did not change their potency or efficacy, indicating that increased rigidity or planarity of the piperine structure does not affect the activity. The opening of the methylenedioxy ring or changes in the heterocyclic ring of the piperine molecule reduced or abolished activity. Furthermore, inactive compounds did not display functional antagonistic activity." @default.
• W2074003525 created "2016-06-24" @default.
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• W2074003525 date "2010-05-01" @default.
• W2074003525 modified "2023-09-29" @default.
• W2074003525 title "In vitro TRPV1 activity of piperine derived amides" @default.
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• W2074003525 doi "https://doi.org/10.1016/j.bmc.2010.03.013" @default.
• W2074003525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20381363" @default.
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