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• W2074003863 abstract "Bacterial enhancer-binding proteins (EBP) activate transcription by hydrolyzing ATP to restructure the σ54-RNA polymerase–promoter complex. We compare six high resolution structures (<2.1 Å) of the AAA+ domain of EBP phage shock protein F (PspF) including apo, AMPPNP, Mg2+-ATP, and ADP forms. These structures permit a description of the atomic details underpinning the origins of the conformational changes occurring during ATP hydrolysis. Conserved regions of PspF's AAA+ domain respond distinctively to nucleotide binding and hydrolysis, suggesting functional roles during the hydrolysis cycle, which completely agree with those derived from activities of PspF mutated at these positions. We propose a putative atomic switch that is responsible for coupling structural changes in the nucleotide-binding site to the repositioning of the σ54-interacting loops. Striking similarities in nucleotide-specific conformational changes and atomic switch exist between PspF and the large T antigen helicase, suggesting conservation in the origin of those events amongst AAA+ proteins." @default.
• W2074003863 created "2016-06-24" @default.
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• W2074003863 date "2006-03-01" @default.
• W2074003863 modified "2023-10-16" @default.
• W2074003863 title "Structural Basis of the Nucleotide Driven Conformational Changes in the AAA+ Domain of Transcription Activator PspF" @default.
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• W2074003863 doi "https://doi.org/10.1016/j.jmb.2005.12.052" @default.
• W2074003863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16430918" @default.
• W2074003863 hasPublicationYear "2006" @default.
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