Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074014431> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2074014431 endingPage "547" @default.
- W2074014431 startingPage "543" @default.
- W2074014431 abstract "Targeted radionuclide therapy (TRT) requires accurate absorbed dose estimation in individual patients. It has been shown that a coumarin-based liquid dosimeter is useful for various phantom geometries of relevance to patient-specific internal dosimetry. The purpose of this study was to refine the performance limits of the coumarin-3-carboxylic acid (CCA) dosimeter using the high-energy β-emitter, Y-90, by measuring the dosimeter's dependence on dose rate, by finding the maximum dose limit, and by comparing measured dose values to those from Monte Carlo (MC) simulation. Non-fluorescent CCA is converted to highly fluorescent 7-hydroxyl-coumarin-3-carboxylic acid (7-OH-CCA) upon irradiation. We measured the Y-90-induced fluorescence from 7-OH-CCA under different conditions. Fluorescence was measured using activity concentrations from 1.1 to 181 MBq/cc, providing initial dose rates from 0.7 to 117 cGy/min. To determine the maximum dose limit, fluorescence was measured for different elapsed times from 4 to 150 h, using a fixed activity concentration, 3.7 MBq/cc. A Cs-137 irradiator was used for calibration, to convert fluorescence measurements to absorbed dose. We calculated absorbed dose using the DOSXYZnrc MC program. We modeled the geometry of cuvettes realistically, including plastic walls, surrounding air, and Y-90 in liquid. S-values of Y-90 in water were calculated using 1-mm cubic voxels. A linear dependence of fluorescence on dose rate was observed up to 80 cGy/min, and the dependence on total dose was linear up to ∼20 Gy The average difference between calculated and measured dose values over 9 samples was 3.6±2%. For our geometry, the dose based on voxel S-values was within 1% of that calculated using MC simulation of the phantom. We refined the performance limits of a CCA-based dosimeter for phantom studies of TRT using Y-90, and confirmed a close agreement between measured and calculated dose values. CCA dosimetry is a promising technique for phantom validation studies of TRT." @default.
- W2074014431 created "2016-06-24" @default.
- W2074014431 creator A5042253073 @default.
- W2074014431 creator A5058353577 @default.
- W2074014431 creator A5078009705 @default.
- W2074014431 creator A5079528320 @default.
- W2074014431 creator A5091281907 @default.
- W2074014431 date "2006-12-01" @default.
- W2074014431 modified "2023-10-17" @default.
- W2074014431 title "Performance of a coumarin-based liquid dosimeter for phantom evaluations of internal dosimetry" @default.
- W2074014431 cites W1984922264 @default.
- W2074014431 cites W1986217883 @default.
- W2074014431 cites W1990794470 @default.
- W2074014431 cites W2045815051 @default.
- W2074014431 cites W2092589754 @default.
- W2074014431 doi "https://doi.org/10.1016/j.nima.2006.08.090" @default.
- W2074014431 hasPublicationYear "2006" @default.
- W2074014431 type Work @default.
- W2074014431 sameAs 2074014431 @default.
- W2074014431 citedByCount "12" @default.
- W2074014431 countsByYear W20740144312014 @default.
- W2074014431 countsByYear W20740144312015 @default.
- W2074014431 countsByYear W20740144312016 @default.
- W2074014431 countsByYear W20740144312018 @default.
- W2074014431 countsByYear W20740144312022 @default.
- W2074014431 crossrefType "journal-article" @default.
- W2074014431 hasAuthorship W2074014431A5042253073 @default.
- W2074014431 hasAuthorship W2074014431A5058353577 @default.
- W2074014431 hasAuthorship W2074014431A5078009705 @default.
- W2074014431 hasAuthorship W2074014431A5079528320 @default.
- W2074014431 hasAuthorship W2074014431A5091281907 @default.
- W2074014431 hasConcept C104293457 @default.
- W2074014431 hasConcept C105636585 @default.
- W2074014431 hasConcept C105795698 @default.
- W2074014431 hasConcept C111337013 @default.
- W2074014431 hasConcept C113196181 @default.
- W2074014431 hasConcept C119128265 @default.
- W2074014431 hasConcept C120665830 @default.
- W2074014431 hasConcept C121332964 @default.
- W2074014431 hasConcept C151337348 @default.
- W2074014431 hasConcept C165838908 @default.
- W2074014431 hasConcept C177322064 @default.
- W2074014431 hasConcept C185544564 @default.
- W2074014431 hasConcept C185592680 @default.
- W2074014431 hasConcept C192562407 @default.
- W2074014431 hasConcept C19499675 @default.
- W2074014431 hasConcept C2989005 @default.
- W2074014431 hasConcept C33923547 @default.
- W2074014431 hasConcept C37160838 @default.
- W2074014431 hasConcept C43617362 @default.
- W2074014431 hasConcept C62520636 @default.
- W2074014431 hasConcept C71924100 @default.
- W2074014431 hasConcept C75088862 @default.
- W2074014431 hasConcept C91881484 @default.
- W2074014431 hasConceptScore W2074014431C104293457 @default.
- W2074014431 hasConceptScore W2074014431C105636585 @default.
- W2074014431 hasConceptScore W2074014431C105795698 @default.
- W2074014431 hasConceptScore W2074014431C111337013 @default.
- W2074014431 hasConceptScore W2074014431C113196181 @default.
- W2074014431 hasConceptScore W2074014431C119128265 @default.
- W2074014431 hasConceptScore W2074014431C120665830 @default.
- W2074014431 hasConceptScore W2074014431C121332964 @default.
- W2074014431 hasConceptScore W2074014431C151337348 @default.
- W2074014431 hasConceptScore W2074014431C165838908 @default.
- W2074014431 hasConceptScore W2074014431C177322064 @default.
- W2074014431 hasConceptScore W2074014431C185544564 @default.
- W2074014431 hasConceptScore W2074014431C185592680 @default.
- W2074014431 hasConceptScore W2074014431C192562407 @default.
- W2074014431 hasConceptScore W2074014431C19499675 @default.
- W2074014431 hasConceptScore W2074014431C2989005 @default.
- W2074014431 hasConceptScore W2074014431C33923547 @default.
- W2074014431 hasConceptScore W2074014431C37160838 @default.
- W2074014431 hasConceptScore W2074014431C43617362 @default.
- W2074014431 hasConceptScore W2074014431C62520636 @default.
- W2074014431 hasConceptScore W2074014431C71924100 @default.
- W2074014431 hasConceptScore W2074014431C75088862 @default.
- W2074014431 hasConceptScore W2074014431C91881484 @default.
- W2074014431 hasIssue "2" @default.
- W2074014431 hasLocation W20740144311 @default.
- W2074014431 hasOpenAccess W2074014431 @default.
- W2074014431 hasPrimaryLocation W20740144311 @default.
- W2074014431 hasRelatedWork W1993414153 @default.
- W2074014431 hasRelatedWork W2012359593 @default.
- W2074014431 hasRelatedWork W2091826309 @default.
- W2074014431 hasRelatedWork W2360473581 @default.
- W2074014431 hasRelatedWork W2623753244 @default.
- W2074014431 hasRelatedWork W2786244108 @default.
- W2074014431 hasRelatedWork W298657778 @default.
- W2074014431 hasRelatedWork W3136758062 @default.
- W2074014431 hasRelatedWork W3137156048 @default.
- W2074014431 hasRelatedWork W4300464951 @default.
- W2074014431 hasVolume "569" @default.
- W2074014431 isParatext "false" @default.
- W2074014431 isRetracted "false" @default.
- W2074014431 magId "2074014431" @default.
- W2074014431 workType "article" @default.