FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074025450> ?p ?o ?g. }

• W2074025450 endingPage "10" @default.
• W2074025450 startingPage "1" @default.
• W2074025450 abstract "Currently no specific biomarkers exist for the screening of pregnancies at risk for down syndrome (DS). Since a quantitative proteomic approach with isobaric labelling (iTRAQ) has recently been suggested to be highly suitable for the discovery of novel plasma biomarkers, we have now used this method to examine for potential quantitative changes in the plasma proteome of the pregnancies bearing DS fetuses in comparison to normal healthy babies. In our study, we used plasma from six women with DS pregnancies and six with uncomplicated pregnancies care were taken to match cases and controls for gestational and maternal age, as these could be a confounder. In our quantitative proteomics analysis we were able to detect 178 proteins using iTRAQ labelling in conjunction with 4800 MALDI TOF/TOF. Amongst these we observed changes in<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>HCG, a known screening marker for DS, indicating that our assay was functional. We found a number of elevated proteins Ig lambda chain C region, serum amyloid P-component, amyloid beta A4, and under expressed proteins like gamma-actin and titin in DS pregnancies. These proteins are also found in the sera of patients with Alzheimer disease, which share similar pathologies of DS. Our study therefore indicates that the iTRAQ labelling approach may be indeed useful for the detection of novel biomarkers." @default.
• W2074025450 created "2016-06-24" @default.
• W2074025450 creator A5016867580 @default.
• W2074025450 creator A5021044213 @default.
• W2074025450 creator A5022692057 @default.
• W2074025450 creator A5036967843 @default.
• W2074025450 creator A5043539179 @default.
• W2074025450 creator A5058876778 @default.
• W2074025450 creator A5075249092 @default.
• W2074025450 date "2010-01-01" @default.
• W2074025450 modified "2023-10-18" @default.
• W2074025450 title "Quantitative Proteomics Analysis of Maternal Plasma in Down Syndrome Pregnancies Using Isobaric Tagging Reagent (iTRAQ)" @default.
• W2074025450 cites W1559666436 @default.
• W2074025450 cites W1971982532 @default.
• W2074025450 cites W1974568266 @default.
• W2074025450 cites W1976837011 @default.
• W2074025450 cites W1996409236 @default.
• W2074025450 cites W2007881272 @default.
• W2074025450 cites W2010011038 @default.
• W2074025450 cites W2024569103 @default.
• W2074025450 cites W2027596874 @default.
• W2074025450 cites W2056745213 @default.
• W2074025450 cites W2063001525 @default.
• W2074025450 cites W2063519987 @default.
• W2074025450 cites W2075198254 @default.
• W2074025450 cites W2096057003 @default.
• W2074025450 cites W2096232789 @default.
• W2074025450 cites W2099837557 @default.
• W2074025450 cites W2107710616 @default.
• W2074025450 cites W2115129497 @default.
• W2074025450 cites W2120016245 @default.
• W2074025450 cites W2121464784 @default.
• W2074025450 cites W2135252110 @default.
• W2074025450 cites W2161348707 @default.
• W2074025450 cites W2168983474 @default.
• W2074025450 cites W2172116519 @default.
• W2074025450 cites W2182322924 @default.
• W2074025450 cites W2601509328 @default.
• W2074025450 doi "https://doi.org/10.1155/2010/952047" @default.
• W2074025450 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2774473" @default.
• W2074025450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19902006" @default.
• W2074025450 hasPublicationYear "2010" @default.
• W2074025450 type Work @default.
• W2074025450 sameAs 2074025450 @default.
• W2074025450 citedByCount "70" @default.
• W2074025450 countsByYear W20740254502012 @default.
• W2074025450 countsByYear W20740254502013 @default.
• W2074025450 countsByYear W20740254502014 @default.
• W2074025450 countsByYear W20740254502015 @default.
• W2074025450 countsByYear W20740254502016 @default.
• W2074025450 countsByYear W20740254502017 @default.
• W2074025450 countsByYear W20740254502018 @default.
• W2074025450 countsByYear W20740254502020 @default.
• W2074025450 countsByYear W20740254502021 @default.
• W2074025450 countsByYear W20740254502022 @default.
• W2074025450 countsByYear W20740254502023 @default.
• W2074025450 crossrefType "journal-article" @default.
• W2074025450 hasAuthorship W2074025450A5016867580 @default.
• W2074025450 hasAuthorship W2074025450A5021044213 @default.
• W2074025450 hasAuthorship W2074025450A5022692057 @default.
• W2074025450 hasAuthorship W2074025450A5036967843 @default.
• W2074025450 hasAuthorship W2074025450A5043539179 @default.
• W2074025450 hasAuthorship W2074025450A5058876778 @default.
• W2074025450 hasAuthorship W2074025450A5075249092 @default.
• W2074025450 hasBestOaLocation W20740254501 @default.
• W2074025450 hasConcept C104317684 @default.
• W2074025450 hasConcept C104397665 @default.
• W2074025450 hasConcept C126322002 @default.
• W2074025450 hasConcept C146543888 @default.
• W2074025450 hasConcept C184185385 @default.
• W2074025450 hasConcept C46111723 @default.
• W2074025450 hasConcept C55493867 @default.
• W2074025450 hasConcept C60644358 @default.
• W2074025450 hasConcept C70721500 @default.
• W2074025450 hasConcept C71924100 @default.
• W2074025450 hasConcept C80311884 @default.
• W2074025450 hasConcept C86803240 @default.
• W2074025450 hasConceptScore W2074025450C104317684 @default.
• W2074025450 hasConceptScore W2074025450C104397665 @default.
• W2074025450 hasConceptScore W2074025450C126322002 @default.
• W2074025450 hasConceptScore W2074025450C146543888 @default.
• W2074025450 hasConceptScore W2074025450C184185385 @default.
• W2074025450 hasConceptScore W2074025450C46111723 @default.
• W2074025450 hasConceptScore W2074025450C55493867 @default.
• W2074025450 hasConceptScore W2074025450C60644358 @default.
• W2074025450 hasConceptScore W2074025450C70721500 @default.
• W2074025450 hasConceptScore W2074025450C71924100 @default.
• W2074025450 hasConceptScore W2074025450C80311884 @default.
• W2074025450 hasConceptScore W2074025450C86803240 @default.
• W2074025450 hasLocation W20740254501 @default.
• W2074025450 hasLocation W20740254502 @default.
• W2074025450 hasLocation W20740254503 @default.
• W2074025450 hasLocation W20740254504 @default.
• W2074025450 hasLocation W20740254505 @default.
• W2074025450 hasOpenAccess W2074025450 @default.
• W2074025450 hasPrimaryLocation W20740254501 @default.
• W2074025450 hasRelatedWork W118701628 @default.
• W2074025450 hasRelatedWork W1970044978 @default.

• next