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• W2074027145 abstract "The preparation of 175Yb-labeled hydroxyapatite (HA) particle is described for possible use as an agent for radiation synovectomy (RS) of small-sized joints. 175Yb was produced by thermal neutron irradiation of enriched (98.6% in 174Yb) ytterbium target at a flux of ∼3×1013 n/cm2/s for 7 days. Specific activity of 5.5-6.0 GBq/mg and a very high radionuclidic purity to the extent of ∼100% were obtained. In the work reported herein, HA could be labeled with 175Yb in very high radiochemical purity (>99%) using 10 mg of HA particle at pH ∼7. The radiolabeled particulates showed excellent in vitro stability at room temperature. Serial scintigraphic images of normal as well as arthritis-bearing Wistar rats following intra-articular injection of 175Yb-HA particles in the knee joint showed complete retention of activity within the synovial cavity with no measurable activity leaching out from the joint till 144 h post-injection." @default.
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• W2074027145 date "2006-05-01" @default.
• W2074027145 modified "2023-09-28" @default.
• W2074027145 title "175Yb-labeled hydroxyapatite: a potential agent for use in radiation synovectomy of small joints" @default.
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• W2074027145 doi "https://doi.org/10.1016/j.nucmedbio.2006.02.004" @default.
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