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- W2074035559 abstract "To support blastocyst implantation and further development of the embryo, the endometrium of mice and humans undergoes a set of processes known as decidualization. Primed by estrogen and progesterone, endometrial fibroblasts transdifferentiate into decidual cells and acquire an epithelial-like phenotype. Decidualization is a remarkably dynamic process, in which cells at different stages of differentiation and of involution coexist in the endometrial stroma. In the mouse, decidualization starts in the antimesometrial wall of endometrium and participates in the formation of the choriovitelline placenta whereas decidualization in the mesometrial wall of the endometrium contributes to the definitive chorioallantoic placenta. Furthermore, orchestrated by ovarian hormones and other mediators, the structure and molecular composition of the endometrial extracellular matrix (ECM) are deeply modified during decidualization. Collectively, the evidence indicates that ECM remodeling is essential to decidualization, and that the decidua is critical for embryo implantation and development." @default.
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- W2074035559 date "1997-08-01" @default.
- W2074035559 modified "2023-09-26" @default.
- W2074035559 title "Splenectomy of pregnant mice does not alter differentiation of uterine natural killer cells at implantation sites" @default.
- W2074035559 doi "https://doi.org/10.1016/s0165-0378(97)90429-0" @default.
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