Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074039400> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2074039400 endingPage "672" @default.
- W2074039400 startingPage "667" @default.
- W2074039400 abstract "A recent double-blind, placebo-controlled trial has shown that prednisone improves strength in patients with Duchenne muscular dystrophy. To determine whether immunosuppressant effects were important in mediating this improvement, we performed immunohistochemical analyses on muscle biopsies obtained at the conclusion of the trial. We studied 33 patients: 12 from the placebo group, nine from the low-dose prednisone group (0.75 mg/kg/d), and 12 from the high-dose group (1.5 mg/kg/d). There was a significant difference in total T cells (CD2+) between the placebo group and both treatment groups. Similarly, the number of CD8+ cytotoxic/suppressor T cells was significantly decreased in both treated groups compared with placebo. The number of muscle fibers focally invaded by lymphocytes was also significantly decreased in the two treated groups compared with controls. There were no differences between the low- and high-dose groups. The numbers of B cells, natural killer cells, CD4+ cells, macrophages, and necrotic muscle fibers were not significantly different in the treated and control groups. This study suggests that prednisone may improve strength in Duchenne muscular dystrophy through primarily immunologic mechanisms involving T lymphocytes." @default.
- W2074039400 created "2016-06-24" @default.
- W2074039400 creator A5047809221 @default.
- W2074039400 creator A5049696879 @default.
- W2074039400 creator A5052220648 @default.
- W2074039400 creator A5083732820 @default.
- W2074039400 date "1991-05-01" @default.
- W2074039400 modified "2023-10-15" @default.
- W2074039400 title "Mononuclear cell analysis of muscle biopsies in prednisone-treated and untreated Duchenne muscular dystrophy" @default.
- W2074039400 doi "https://doi.org/10.1212/wnl.41.5.667" @default.
- W2074039400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2027481" @default.
- W2074039400 hasPublicationYear "1991" @default.
- W2074039400 type Work @default.
- W2074039400 sameAs 2074039400 @default.
- W2074039400 citedByCount "91" @default.
- W2074039400 countsByYear W20740394002012 @default.
- W2074039400 countsByYear W20740394002013 @default.
- W2074039400 countsByYear W20740394002014 @default.
- W2074039400 countsByYear W20740394002015 @default.
- W2074039400 countsByYear W20740394002016 @default.
- W2074039400 countsByYear W20740394002017 @default.
- W2074039400 countsByYear W20740394002018 @default.
- W2074039400 countsByYear W20740394002019 @default.
- W2074039400 countsByYear W20740394002020 @default.
- W2074039400 countsByYear W20740394002021 @default.
- W2074039400 countsByYear W20740394002022 @default.
- W2074039400 countsByYear W20740394002023 @default.
- W2074039400 crossrefType "journal-article" @default.
- W2074039400 hasAuthorship W2074039400A5047809221 @default.
- W2074039400 hasAuthorship W2074039400A5049696879 @default.
- W2074039400 hasAuthorship W2074039400A5052220648 @default.
- W2074039400 hasAuthorship W2074039400A5083732820 @default.
- W2074039400 hasConcept C126322002 @default.
- W2074039400 hasConcept C134018914 @default.
- W2074039400 hasConcept C137061746 @default.
- W2074039400 hasConcept C142724271 @default.
- W2074039400 hasConcept C167672396 @default.
- W2074039400 hasConcept C202751555 @default.
- W2074039400 hasConcept C203014093 @default.
- W2074039400 hasConcept C204232928 @default.
- W2074039400 hasConcept C204787440 @default.
- W2074039400 hasConcept C27081682 @default.
- W2074039400 hasConcept C2778720950 @default.
- W2074039400 hasConcept C2778943923 @default.
- W2074039400 hasConcept C2779030066 @default.
- W2074039400 hasConcept C55493867 @default.
- W2074039400 hasConcept C71924100 @default.
- W2074039400 hasConcept C86803240 @default.
- W2074039400 hasConcept C8891405 @default.
- W2074039400 hasConcept C90924648 @default.
- W2074039400 hasConceptScore W2074039400C126322002 @default.
- W2074039400 hasConceptScore W2074039400C134018914 @default.
- W2074039400 hasConceptScore W2074039400C137061746 @default.
- W2074039400 hasConceptScore W2074039400C142724271 @default.
- W2074039400 hasConceptScore W2074039400C167672396 @default.
- W2074039400 hasConceptScore W2074039400C202751555 @default.
- W2074039400 hasConceptScore W2074039400C203014093 @default.
- W2074039400 hasConceptScore W2074039400C204232928 @default.
- W2074039400 hasConceptScore W2074039400C204787440 @default.
- W2074039400 hasConceptScore W2074039400C27081682 @default.
- W2074039400 hasConceptScore W2074039400C2778720950 @default.
- W2074039400 hasConceptScore W2074039400C2778943923 @default.
- W2074039400 hasConceptScore W2074039400C2779030066 @default.
- W2074039400 hasConceptScore W2074039400C55493867 @default.
- W2074039400 hasConceptScore W2074039400C71924100 @default.
- W2074039400 hasConceptScore W2074039400C86803240 @default.
- W2074039400 hasConceptScore W2074039400C8891405 @default.
- W2074039400 hasConceptScore W2074039400C90924648 @default.
- W2074039400 hasIssue "5" @default.
- W2074039400 hasLocation W20740394001 @default.
- W2074039400 hasLocation W20740394002 @default.
- W2074039400 hasOpenAccess W2074039400 @default.
- W2074039400 hasPrimaryLocation W20740394001 @default.
- W2074039400 hasRelatedWork W1912221966 @default.
- W2074039400 hasRelatedWork W1986232328 @default.
- W2074039400 hasRelatedWork W2087092604 @default.
- W2074039400 hasRelatedWork W2152841871 @default.
- W2074039400 hasRelatedWork W2175838118 @default.
- W2074039400 hasRelatedWork W2370501894 @default.
- W2074039400 hasRelatedWork W2414858669 @default.
- W2074039400 hasRelatedWork W2580749893 @default.
- W2074039400 hasRelatedWork W4225244479 @default.
- W2074039400 hasRelatedWork W4254397730 @default.
- W2074039400 hasVolume "41" @default.
- W2074039400 isParatext "false" @default.
- W2074039400 isRetracted "false" @default.
- W2074039400 magId "2074039400" @default.
- W2074039400 workType "article" @default.