FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074044765> ?p ?o ?g. }

• W2074044765 endingPage "2692" @default.
• W2074044765 startingPage "2685" @default.
• W2074044765 abstract "The purpose of this study was to evaluate the effectiveness of a novel fluorocarbon-based sevoflurane emulsion in dogs previously shown to produce short-term rodent anesthesia. On the basis of an unexpected allergic-type clinical reaction, we also tested the hypothesis that this type of formulation causes histamine release and complement activation. Physiological parameters, plasma histamine levels (radioimmunoassay), and complement activation (enzyme immunoassay) were quantified in response to emulsion components, including F13M5 (the emulsion's fluorocarbon-based polymer) and methoxy poly(ethylene glycol) 5000 (the polymer's hydrophilic block). Although the emulsion produced general anesthesia in dogs, they also experienced hypotension and clinical signs suggestive of an allergic-like response (i.e., vasodilation, urticaria, and pruritus upon recovery). Emulsions lacking sevoflurane failed to induce anesthesia but did elicit the allergic response. Plasma histamine levels were significantly increased following injection of micellar solutions of F13M5. Direct complement activation by the emulsion or its components was weak or absent. An allergic response leading to histamine release, likely initiated by the F13M5 component via an immunoglobulin pathway, is associated with an intravenous fluorocarbon-based emulsion of sevoflurane. Subsequently, its usefulness in medicine in its present formulation is limited. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:2685–2692, 2011 The purpose of this study was to evaluate the effectiveness of a novel fluorocarbon-based sevoflurane emulsion in dogs previously shown to produce short-term rodent anesthesia. On the basis of an unexpected allergic-type clinical reaction, we also tested the hypothesis that this type of formulation causes histamine release and complement activation. Physiological parameters, plasma histamine levels (radioimmunoassay), and complement activation (enzyme immunoassay) were quantified in response to emulsion components, including F13M5 (the emulsion's fluorocarbon-based polymer) and methoxy poly(ethylene glycol) 5000 (the polymer's hydrophilic block). Although the emulsion produced general anesthesia in dogs, they also experienced hypotension and clinical signs suggestive of an allergic-like response (i.e., vasodilation, urticaria, and pruritus upon recovery). Emulsions lacking sevoflurane failed to induce anesthesia but did elicit the allergic response. Plasma histamine levels were significantly increased following injection of micellar solutions of F13M5. Direct complement activation by the emulsion or its components was weak or absent. An allergic response leading to histamine release, likely initiated by the F13M5 component via an immunoglobulin pathway, is associated with an intravenous fluorocarbon-based emulsion of sevoflurane. Subsequently, its usefulness in medicine in its present formulation is limited. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:2685–2692, 2011" @default.
• W2074044765 created "2016-06-24" @default.
• W2074044765 creator A5012676423 @default.
• W2074044765 creator A5040639533 @default.
• W2074044765 creator A5044659783 @default.
• W2074044765 creator A5062340234 @default.
• W2074044765 creator A5081366098 @default.
• W2074044765 creator A5087838557 @default.
• W2074044765 creator A5088965162 @default.
• W2074044765 date "2011-07-01" @default.
• W2074044765 modified "2023-10-10" @default.
• W2074044765 title "Histamine Release Associated with Intravenous Delivery of a Fluorocarbon-Based Sevoflurane Emulsion in Canines" @default.
• W2074044765 cites W1772139940 @default.
• W2074044765 cites W1974526584 @default.
• W2074044765 cites W1985541331 @default.
• W2074044765 cites W1990622580 @default.
• W2074044765 cites W1997051385 @default.
• W2074044765 cites W2004838689 @default.
• W2074044765 cites W2007102329 @default.
• W2074044765 cites W2040258388 @default.
• W2074044765 cites W2050815703 @default.
• W2074044765 cites W2075020461 @default.
• W2074044765 cites W2076675707 @default.
• W2074044765 cites W2083136075 @default.
• W2074044765 cites W2112852178 @default.
• W2074044765 cites W2145719807 @default.
• W2074044765 cites W2155306495 @default.
• W2074044765 doi "https://doi.org/10.1002/jps.22488" @default.
• W2074044765 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3102263" @default.
• W2074044765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21246564" @default.
• W2074044765 hasPublicationYear "2011" @default.
• W2074044765 type Work @default.
• W2074044765 sameAs 2074044765 @default.
• W2074044765 citedByCount "18" @default.
• W2074044765 countsByYear W20740447652012 @default.
• W2074044765 countsByYear W20740447652013 @default.
• W2074044765 countsByYear W20740447652014 @default.
• W2074044765 countsByYear W20740447652016 @default.
• W2074044765 countsByYear W20740447652017 @default.
• W2074044765 countsByYear W20740447652018 @default.
• W2074044765 countsByYear W20740447652019 @default.
• W2074044765 countsByYear W20740447652020 @default.
• W2074044765 countsByYear W20740447652021 @default.
• W2074044765 countsByYear W20740447652023 @default.
• W2074044765 crossrefType "journal-article" @default.
• W2074044765 hasAuthorship W2074044765A5012676423 @default.
• W2074044765 hasAuthorship W2074044765A5040639533 @default.
• W2074044765 hasAuthorship W2074044765A5044659783 @default.
• W2074044765 hasAuthorship W2074044765A5062340234 @default.
• W2074044765 hasAuthorship W2074044765A5081366098 @default.
• W2074044765 hasAuthorship W2074044765A5087838557 @default.
• W2074044765 hasAuthorship W2074044765A5088965162 @default.
• W2074044765 hasBestOaLocation W20740447652 @default.
• W2074044765 hasConcept C1122143 @default.
• W2074044765 hasConcept C185592680 @default.
• W2074044765 hasConcept C2776954882 @default.
• W2074044765 hasConcept C2778123984 @default.
• W2074044765 hasConcept C2781453256 @default.
• W2074044765 hasConcept C42219234 @default.
• W2074044765 hasConcept C55493867 @default.
• W2074044765 hasConcept C71924100 @default.
• W2074044765 hasConcept C98274493 @default.
• W2074044765 hasConceptScore W2074044765C1122143 @default.
• W2074044765 hasConceptScore W2074044765C185592680 @default.
• W2074044765 hasConceptScore W2074044765C2776954882 @default.
• W2074044765 hasConceptScore W2074044765C2778123984 @default.
• W2074044765 hasConceptScore W2074044765C2781453256 @default.
• W2074044765 hasConceptScore W2074044765C42219234 @default.
• W2074044765 hasConceptScore W2074044765C55493867 @default.
• W2074044765 hasConceptScore W2074044765C71924100 @default.
• W2074044765 hasConceptScore W2074044765C98274493 @default.
• W2074044765 hasIssue "7" @default.
• W2074044765 hasLocation W20740447651 @default.
• W2074044765 hasLocation W20740447652 @default.
• W2074044765 hasLocation W20740447653 @default.
• W2074044765 hasLocation W20740447654 @default.
• W2074044765 hasOpenAccess W2074044765 @default.
• W2074044765 hasPrimaryLocation W20740447651 @default.
• W2074044765 hasRelatedWork W1979646284 @default.
• W2074044765 hasRelatedWork W2007093242 @default.
• W2074044765 hasRelatedWork W2043197312 @default.
• W2074044765 hasRelatedWork W2074440122 @default.
• W2074044765 hasRelatedWork W2128164030 @default.
• W2074044765 hasRelatedWork W2355405161 @default.
• W2074044765 hasRelatedWork W2469966616 @default.
• W2074044765 hasRelatedWork W2588543877 @default.
• W2074044765 hasRelatedWork W2591374869 @default.
• W2074044765 hasRelatedWork W3029861768 @default.
• W2074044765 hasVolume "100" @default.
• W2074044765 isParatext "false" @default.
• W2074044765 isRetracted "false" @default.
• W2074044765 magId "2074044765" @default.
• W2074044765 workType "article" @default.