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- W2074048186 abstract "1 We have shown previously that exposing the rat or rabbit microcirculation to nifedipine increases the permeability of the post-capillary venule, the segment of microcirculation that is known to control inflammatory oedema. 2 In the present study modulation by the inotropes isoprenaline, dopexamine and dobutamine of nifedipine-induced oedema was examined in the rabbit skin microcirculation by measuring the localised leakage of 125I-radiolabelled albumin after the i.d. injection of agents. 3 Coinjection of isoprenaline (10−11 moles per site), dopexamine (10−10 moles per site) or dobutamine (10−10 moles per site) suppressed significantly (P<0.05) the oedema response to nifedipine (10−7.2 moles per site) in the rabbit dorsal skin microcirculation. 4 To confirm the oedema suppresser effect of the inotropes, dopexamine or dobutamine were also coinjected with histamine 10−8 +PGE2 10−10 moles per site, or bradykinin 10−10+PGE2 10−10 moles per site. Both inotropes at 10−10 moles per site reduced significantly (P<0.05) the leakage of albumin caused by bradykinin+PGE2 and histamine+PGE2. 5 When measured by laser Doppler, basal local skin blood flow increased at 30 min by 57±14% with nifedipine 10−7.2 moles per site and 15±11% with isoprenaline 10−11 moles per site. Isoprenaline did not suppress the blood flow response to nifedipine, the response to coinjection being 68±11%. 6 Oedema caused by nifedipine can be suppressed by low concentrations of β-adrenergic agonists that do not suppress the blood flow response to nifedipine. This suggests that cardiac inotropes can influence non-inflammatory changes in microvascular permeability. British Journal of Pharmacology (1997) 122, 1160–1164; doi:10.1038/sj.bjp.0701480" @default.
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- W2074048186 date "1997-11-01" @default.
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- W2074048186 title "Cardiac inotropes inhibit the oedema caused by nifedipine in rabbit skin" @default.
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- W2074048186 doi "https://doi.org/10.1038/sj.bjp.0701480" @default.
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