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- W2074053811 abstract "Cellular senescence is a physiological process of irreversible cell-cycle arrest that contributes to various physiological and pathological processes of aging. Whereas replicative senescence is associated with telomere attrition after repeated cell division, stress-induced premature senescence occurs in response to aberrant oncogenic signaling, oxidative stress, and DNA damage which is independent of telomere dysfunction. Recent evidence indicates that cellular senescence provides a barrier to tumorigenesis and is a determinant of the outcome of cancer treatment. However, the senescence-associated secretory phenotype, which contributes to multiple facets of senescent cancer cells, may influence both cancer-inhibitory and cancer-promoting mechanisms of neighboring cells. Conventional treatments, such as chemo- and radiotherapies, preferentially induce premature senescence instead of apoptosis in the appropriate cellular context. In addition, treatment-induced premature senescence could compensate for resistance to apoptosis via alternative signaling pathways. Therefore, we believe that an intensive effort to understand cancer cell senescence could facilitate the development of novel therapeutic strategies for improving the efficacy of anticancer therapies. This review summarizes the current understanding of molecular mechanisms, functions, and clinical applications of cellular senescence for anticancer therapy." @default.
- W2074053811 created "2016-06-24" @default.
- W2074053811 creator A5011771218 @default.
- W2074053811 creator A5051335583 @default.
- W2074053811 date "2014-02-28" @default.
- W2074053811 modified "2023-09-30" @default.
- W2074053811 title "Exploiting tumor cell senescence in anticancer therapy" @default.
- W2074053811 cites W1526615021 @default.
- W2074053811 cites W1964440144 @default.
- W2074053811 cites W1969850649 @default.
- W2074053811 cites W1970594724 @default.
- W2074053811 cites W1970733036 @default.
- W2074053811 cites W1977122455 @default.
- W2074053811 cites W1977361069 @default.
- W2074053811 cites W1977800604 @default.
- W2074053811 cites W1977972521 @default.
- W2074053811 cites W1982395176 @default.
- W2074053811 cites W1982580926 @default.
- W2074053811 cites W1991258133 @default.
- W2074053811 cites W1994474279 @default.
- W2074053811 cites W1996113298 @default.
- W2074053811 cites W1997023365 @default.
- W2074053811 cites W1998051584 @default.
- W2074053811 cites W1998616828 @default.
- W2074053811 cites W1998770945 @default.
- W2074053811 cites W2001720505 @default.
- W2074053811 cites W2004273407 @default.
- W2074053811 cites W2005250235 @default.
- W2074053811 cites W2007128892 @default.
- W2074053811 cites W2009703979 @default.
- W2074053811 cites W2011997876 @default.
- W2074053811 cites W2012099961 @default.
- W2074053811 cites W2016375116 @default.
- W2074053811 cites W2018321060 @default.
- W2074053811 cites W2019544036 @default.
- W2074053811 cites W2031541891 @default.
- W2074053811 cites W2037611415 @default.
- W2074053811 cites W2042140414 @default.
- W2074053811 cites W2042418128 @default.
- W2074053811 cites W2047119143 @default.
- W2074053811 cites W2050852029 @default.
- W2074053811 cites W2050880607 @default.
- W2074053811 cites W2051379856 @default.
- W2074053811 cites W2057254600 @default.
- W2074053811 cites W2062400207 @default.
- W2074053811 cites W2065891752 @default.
- W2074053811 cites W2067117191 @default.
- W2074053811 cites W2080077392 @default.
- W2074053811 cites W2081779271 @default.
- W2074053811 cites W2082400500 @default.
- W2074053811 cites W2083594352 @default.
- W2074053811 cites W2085197755 @default.
- W2074053811 cites W2085351616 @default.
- W2074053811 cites W2085498425 @default.
- W2074053811 cites W2085837709 @default.
- W2074053811 cites W2086598375 @default.
- W2074053811 cites W2087404852 @default.
- W2074053811 cites W2087590639 @default.
- W2074053811 cites W2088468764 @default.
- W2074053811 cites W2091369486 @default.
- W2074053811 cites W2092333751 @default.
- W2074053811 cites W2092902276 @default.
- W2074053811 cites W2098873966 @default.
- W2074053811 cites W2104908670 @default.
- W2074053811 cites W2108700752 @default.
- W2074053811 cites W2110934787 @default.
- W2074053811 cites W2115852450 @default.
- W2074053811 cites W2116437342 @default.
- W2074053811 cites W2120572492 @default.
- W2074053811 cites W2122846804 @default.
- W2074053811 cites W2126525177 @default.
- W2074053811 cites W2128667978 @default.
- W2074053811 cites W2128668256 @default.
- W2074053811 cites W2133388626 @default.
- W2074053811 cites W2135829603 @default.
- W2074053811 cites W2136380412 @default.
- W2074053811 cites W2136522433 @default.
- W2074053811 cites W2144626763 @default.
- W2074053811 cites W2150740687 @default.
- W2074053811 cites W2150748567 @default.
- W2074053811 cites W2151807108 @default.
- W2074053811 cites W2154349362 @default.
- W2074053811 cites W2154799239 @default.
- W2074053811 cites W2157459126 @default.
- W2074053811 cites W2157962067 @default.
- W2074053811 cites W2158435332 @default.
- W2074053811 cites W2158862873 @default.
- W2074053811 cites W2160149903 @default.
- W2074053811 cites W2168887745 @default.
- W2074053811 cites W4251068277 @default.
- W2074053811 doi "https://doi.org/10.5483/bmbrep.2014.47.2.005" @default.
- W2074053811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4163898" @default.
- W2074053811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24411464" @default.
- W2074053811 hasPublicationYear "2014" @default.
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