Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074055125> ?p ?o ?g. }
- W2074055125 endingPage "41" @default.
- W2074055125 startingPage "35" @default.
- W2074055125 abstract "Endothelial dysfunction is an important factor in the pathogenesis of atherosclerosis, hypertension, and heart failure. The endothelium mediates vascular tone, structure, and function by the release and regulation of multiple vasoactive substances that promote or inhibit vasodilation, vasoconstriction, cell growth, and other mechanisms. The effect of antihypertensive drugs on endothelial function may be an important indicator of their ability to reduce risks for cardiovascular morbidity and mortality. Endothelium-dependent vasodilation induced by various antihypertensive drugs is accurately measured with high-resolution ultrasound of flow-mediated dilation of the brachial artery. Calcium channel blockers and angiotensin-converting enzyme inhibitors have been shown to reverse endothelial dysfunction. The benefits of angiotensin-converting enzyme inhibitors and calcium channel blockers on the endothelium are believed to derive from their effects on nitric oxide production and antioxidant effects, possibly independent of blood pressure reduction. Due to their complementary mechanisms of action, it has been hypothesized that the combination of an angiotensin-converting enzyme inhibitor and a calcium channel blocker will provide superior cardiovascular protection, in part by producing an additive effect of increased nitric oxide availability, when compared with either agent alone." @default.
- W2074055125 created "2016-06-24" @default.
- W2074055125 creator A5020782307 @default.
- W2074055125 date "2006-01-01" @default.
- W2074055125 modified "2023-10-16" @default.
- W2074055125 title "Optimal Vascular Protection: A Case for Combination Antihypertensive Therapy" @default.
- W2074055125 cites W1555489744 @default.
- W2074055125 cites W1967578199 @default.
- W2074055125 cites W1976213519 @default.
- W2074055125 cites W1979225573 @default.
- W2074055125 cites W1980445357 @default.
- W2074055125 cites W1983790951 @default.
- W2074055125 cites W1985039207 @default.
- W2074055125 cites W1992202750 @default.
- W2074055125 cites W1993168719 @default.
- W2074055125 cites W1993378083 @default.
- W2074055125 cites W2014639523 @default.
- W2074055125 cites W2016342558 @default.
- W2074055125 cites W2016880082 @default.
- W2074055125 cites W2018106877 @default.
- W2074055125 cites W2019044547 @default.
- W2074055125 cites W2020455366 @default.
- W2074055125 cites W2032533075 @default.
- W2074055125 cites W2034431661 @default.
- W2074055125 cites W2037365395 @default.
- W2074055125 cites W2037417530 @default.
- W2074055125 cites W2038804822 @default.
- W2074055125 cites W2040463508 @default.
- W2074055125 cites W2042027402 @default.
- W2074055125 cites W2057116025 @default.
- W2074055125 cites W2061107276 @default.
- W2074055125 cites W2070726999 @default.
- W2074055125 cites W2070763907 @default.
- W2074055125 cites W2071143898 @default.
- W2074055125 cites W2073353638 @default.
- W2074055125 cites W2083296849 @default.
- W2074055125 cites W2083481797 @default.
- W2074055125 cites W2083849950 @default.
- W2074055125 cites W2084953640 @default.
- W2074055125 cites W2087780444 @default.
- W2074055125 cites W2089988280 @default.
- W2074055125 cites W2091181219 @default.
- W2074055125 cites W2091301735 @default.
- W2074055125 cites W2091904198 @default.
- W2074055125 cites W2100836459 @default.
- W2074055125 cites W2105279305 @default.
- W2074055125 cites W2105767342 @default.
- W2074055125 cites W2110182057 @default.
- W2074055125 cites W2124359761 @default.
- W2074055125 cites W2128021959 @default.
- W2074055125 cites W2137570167 @default.
- W2074055125 cites W2137902919 @default.
- W2074055125 cites W2141443485 @default.
- W2074055125 cites W2143977823 @default.
- W2074055125 cites W2145899271 @default.
- W2074055125 cites W2147483495 @default.
- W2074055125 cites W2155766891 @default.
- W2074055125 cites W2166264084 @default.
- W2074055125 cites W2170831516 @default.
- W2074055125 cites W2328103583 @default.
- W2074055125 cites W2334245785 @default.
- W2074055125 cites W2334425173 @default.
- W2074055125 cites W2341645956 @default.
- W2074055125 cites W2617392052 @default.
- W2074055125 cites W62127090 @default.
- W2074055125 doi "https://doi.org/10.1111/j.1520-037x.2006.4473.x" @default.
- W2074055125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16407701" @default.
- W2074055125 hasPublicationYear "2006" @default.
- W2074055125 type Work @default.
- W2074055125 sameAs 2074055125 @default.
- W2074055125 citedByCount "5" @default.
- W2074055125 countsByYear W20740551252017 @default.
- W2074055125 countsByYear W20740551252022 @default.
- W2074055125 crossrefType "journal-article" @default.
- W2074055125 hasAuthorship W2074055125A5020782307 @default.
- W2074055125 hasBestOaLocation W20740551251 @default.
- W2074055125 hasConcept C120770815 @default.
- W2074055125 hasConcept C126322002 @default.
- W2074055125 hasConcept C164705383 @default.
- W2074055125 hasConcept C27016395 @default.
- W2074055125 hasConcept C2776992346 @default.
- W2074055125 hasConcept C2777604165 @default.
- W2074055125 hasConcept C2779961880 @default.
- W2074055125 hasConcept C2780356492 @default.
- W2074055125 hasConcept C2780972559 @default.
- W2074055125 hasConcept C2908929049 @default.
- W2074055125 hasConcept C519063684 @default.
- W2074055125 hasConcept C519581460 @default.
- W2074055125 hasConcept C71924100 @default.
- W2074055125 hasConcept C84393581 @default.
- W2074055125 hasConcept C85520022 @default.
- W2074055125 hasConcept C98274493 @default.
- W2074055125 hasConceptScore W2074055125C120770815 @default.
- W2074055125 hasConceptScore W2074055125C126322002 @default.
- W2074055125 hasConceptScore W2074055125C164705383 @default.
- W2074055125 hasConceptScore W2074055125C27016395 @default.
- W2074055125 hasConceptScore W2074055125C2776992346 @default.
- W2074055125 hasConceptScore W2074055125C2777604165 @default.